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10.1038/ni.2960 http://scihub22266oqcxt.onion/10.1038/ni.2960 C4251968!4251968 !25129370     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25129370 &cmd=llinks): Failed to open stream: HTTP request failed! 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A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells |pdf=|usr=}}{{25129370 }} gab.com Text A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the integrity and amplitude of effector responses and was required for proper differentiation of types 1 and 2 helper T cells in vivo by restraining the expression and function of Runx3, a nuclear factor crucial for cytotoxic T cell differentiation. The transcription factor LRF acts redundantly with ThPOK to prevent the transdifferentiation of mature CD4(+) T cells into CD8(+) T cells. As such, the ThPOK-LRF transcriptional module was essential for CD4(+) T cell integrity and responses. Twit Text FOAVip A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip English Wikipedia <ref>{{Cite pmid|25129370 }}</ref> A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells #MMPMID25129370 Vacchio MS ; Wang L ; Bouladoux N ; Carpenter AC ; Xiong Y ; Williams LC ; Wohlfert E ; Song KD ; Belkaid Y ; Love PE ; Bosselut R Nat Immunol 2014[Oct]; 15 (10 ): 947-56 PMID25129370 show ga The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the integrity and amplitude of effector responses and was required for proper differentiation of types 1 and 2 helper T cells in vivo by restraining the expression and function of Runx3, a nuclear factor crucial for cytotoxic T cell differentiation. The transcription factor LRF acts redundantly with ThPOK to prevent the transdifferentiation of mature CD4(+) T cells into CD8(+) T cells. As such, the ThPOK-LRF transcriptional module was essential for CD4(+) T cell integrity and responses. |Animals [MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism [MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism [MESH] |Cell Differentiation/immunology [MESH] |Cell Lineage/genetics/immunology [MESH] |Core Binding Factor Alpha 3 Subunit/genetics/immunology/metabolism [MESH] |DNA-Binding Proteins/genetics/*immunology/metabolism [MESH] |Flow Cytometry [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Th1 Cells/immunology/metabolism [MESH] |Th2 Cells/immunology/metabolism [MESH] |Thymus Gland/*immunology/metabolism [MESH] |Transcription Factors/genetics/*immunology/metabolism [MESH]A ThPOK-LRF transcriptional node maintains the integrity and effector (epmc).pdf DeepDyve Pubget Overpricing