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10.1016/j.det.2014.03.005

http://scihub22266oqcxt.onion/10.1016/j.det.2014.03.005
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C4251714!4251714!24891051
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suck abstract from ncbi

pmid24891051      Dermatol+Clin 2014 ; 32 (3): 277-vii
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  • PHOTOIMMUNOLOGY #MMPMID24891051
  • Elmets CA; Calla C; Xu H
  • Dermatol Clin 2014[Jul]; 32 (3): 277-vii PMID24891051show ga
  • The discipline that investigates the biological effects of ultraviolet radiation on the immune system is called photoimmunology. Photoimmunology evolved from an interest in understanding the role of the immune system in skin cancer development, and why immunosuppressed organ transplant recipients are at greatly increased risk for cutaneous neoplasms. Ultraviolet radiation-induced damage DNA modifies the antigen presenting function of cutaneous dendritic cells, biases the immune response towards the generation of regulatory T-cells and stimulates epidermal keratinocyte production of immunosuppressive cytokines. In addition to contributing to an understanding of the pathogenesis of non-melanoma skin cancer, the knowledge acquired about the immunological effects of ultraviolet radiation exposure has provided an understanding of its role in the pathogenesis of other photodermatologic diseases such as polymorphous light eruption, chronic actinic dermatitis and cutaneous lupus erythematosus. This information has also been helpful in developing more effective and safer phototherapeutic devices for the treatment of a variety of cutaneous diseases.
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