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10.1093/toxsci/kfu194 http://scihub22266oqcxt.onion/10.1093/toxsci/kfu194 C4250848!4250848 !25239634     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25239634 &cmd=llinks): Failed to open stream: HTTP request failed! 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Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio) |pdf=|usr=}}{{25239634 }} gab.com Text Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio) JO: Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25239634 #FOAvip Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs are structurally similar to organophosphate pesticides and may adversely affect the developing nervous system. This study evaluated the overt toxicity, uptake, and neurobehavioral effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCPP), and tris (2,3-dibromopropyl) phosphate (TDBPP) in early life stage zebrafish. Chlorpyrifos was used as a positive control. For overt toxicity and neurobehavioral assessments, zebrafish were exposed from 0 to 5 days postfertilization (dpf). Hatching, death, or malformations were evaluated daily. Teratogenic effects were scored by visual examination on 6 dpf. To evaluate uptake and metabolism, zebrafish were exposed to 1?然 of each organophosphate (OP) flame retardant and collected on 1 and 5 dpf to monitor accumulation. Larval swimming activity was measured in 6 dpf larvae to evaluate neurobehavioral effects of exposures below the acute toxicity threshold. TDBPP elicited the greatest toxicity at >1?然. TDCPP and chlorpyrifos were overtly toxic at concentrations ?10?然, TCEP, and TCPP were not overtly toxic at the doses tested. Tissue concentrations increased with increasing hydrophobicity of the parent chemical after 24?h exposures. TDCPP and TDBPP and their respective metabolites were detected in embryos on 5 dpf. For all chemicals tested, developmental exposures that were not overtly toxic significantly altered larval swimming activity. These data indicate that OPFRs adversely affect development of early life stage zebrafish. Twit Text FOAVip Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio) ????Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25239634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25239634 #FOAvip English Wikipedia <ref>{{Cite pmid|25239634 }}</ref> Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio) #MMPMID25239634 Dishaw LV ; Hunter DL ; Padnos B ; Padilla S ; Stapleton HM Toxicol Sci 2014[Dec]; 142 (2 ): 445-54 PMID25239634 show ga Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs are structurally similar to organophosphate pesticides and may adversely affect the developing nervous system. This study evaluated the overt toxicity, uptake, and neurobehavioral effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCPP), and tris (2,3-dibromopropyl) phosphate (TDBPP) in early life stage zebrafish. Chlorpyrifos was used as a positive control. For overt toxicity and neurobehavioral assessments, zebrafish were exposed from 0 to 5 days postfertilization (dpf). Hatching, death, or malformations were evaluated daily. Teratogenic effects were scored by visual examination on 6 dpf. To evaluate uptake and metabolism, zebrafish were exposed to 1?然 of each organophosphate (OP) flame retardant and collected on 1 and 5 dpf to monitor accumulation. Larval swimming activity was measured in 6 dpf larvae to evaluate neurobehavioral effects of exposures below the acute toxicity threshold. TDBPP elicited the greatest toxicity at >1?然. TDCPP and chlorpyrifos were overtly toxic at concentrations ?10?然, TCEP, and TCPP were not overtly toxic at the doses tested. Tissue concentrations increased with increasing hydrophobicity of the parent chemical after 24?h exposures. TDCPP and TDBPP and their respective metabolites were detected in embryos on 5 dpf. For all chemicals tested, developmental exposures that were not overtly toxic significantly altered larval swimming activity. These data indicate that OPFRs adversely affect development of early life stage zebrafish. |*Abnormalities, Drug-Induced/etiology/psychology [MESH] |Animals [MESH] |Behavior, Animal/*drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Embryo, Nonmammalian/drug effects [MESH] |Embryonic Development/*drug effects [MESH] |Flame Retardants/pharmacokinetics/*toxicity [MESH] |Molecular Structure [MESH] |Nervous System/drug effects/embryology [MESH] |Organophosphates/chemistry/pharmacokinetics/*toxicity [MESH] |Survival Analysis [MESH] |Swimming [MESH]Developmental exposure to organophosphate flame retardants elicits ove(epmc).pdf DeepDyve Pubget Overpricing