Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24990891
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24990891
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Physiol+Renal+Physiol
2014 ; 307
(5
): F533-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive
rats: role of 20-HETE
#MMPMID24990891
Ren Y
; D'Ambrosio MA
; Garvin JL
; Peterson EL
; Carretero OA
Am J Physiol Renal Physiol
2014[Sep]; 307
(5
): F533-8
PMID24990891
show ga
The afferent arteriole (Af-Art) controls glomerular capillary pressure, an
important determinant of glomerular injury. Af-Art myogenic response is mediated
by ATP, and ATP signaling is in turn mediated by 20-HETE. Dahl salt-sensitive
rats (Dahl SS) have decreased renal 20-HETE production. We hypothesized that Dahl
SS have an impaired myogenic response and constrictor response to ATP, due to
decreased 20-HETE. Af-Arts from Dahl SS or Dahl salt-resistant rats (Dahl SR)
were microdissected and perfused. When myogenic response was induced by
increasing Af-Art perfusion pressure from 60 to 140 mmHg, luminal Af-Art diameter
decreased in Dahl SR but not in Dahl SS (-3.1 ± 0.8 vs. 0.5 ± 0.8 ?m, P < 0.01).
The 20-HETE antagonist 20-HEDE (10(-6) M) blocked the myogenic response in Dahl
SR but had no effect in Dahl SS. Addition of a subconstrictor concentration of
20-HETE (but not a subconstrictor concentration of norepinephrine) restored the
myogenic response in Dahl SS. We then perfused Af-Arts at 60 mmHg and tested the
effects of the ATP analog ?,?-methylene-ATP (10(-6) M). Maximum ATP-induced
constriction was attenuated in Dahl SS compared with Dahl SR (1.5 ± 0.5 vs. 7.4 ±
0.8 ?m, P < 0.001). 20-HEDE attenuated ATP-induced Af-Art constriction in Dahl SR
but not in Dahl SS, and consequently, ATP-induced constriction was no longer
different between strains. In conclusion, Dahl SS have an impaired myogenic
response and ATP-induced Af-Art constriction due to a decrease in Af-Art 20-HETE.
The impaired myogenic responses may contribute to the nephrosclerosis that
develops in Dahl SS.
free
free
free
