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10.5966/sctm.2014-0131

http://scihub22266oqcxt.onion/10.5966/sctm.2014-0131
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C4250215!4250215!25411475
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suck abstract from ncbi


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pmid25411475      Stem+Cells+Transl+Med 2014 ; 3 (12): 1444-50
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  • Adipose-Derived Stromal Cells Promote Allograft Tolerance Induction #MMPMID25411475
  • Davis TA; Anam K; Lazdun Y; Gimble JM; Elster EA
  • Stem Cells Transl Med 2014[Dec]; 3 (12): 1444-50 PMID25411475show ga
  • The ability of adipose-derived stromal/stem cells (ASCs) to facilitate long-term allograft survival was investigated. ASC and bone marrow cell (BMC) coinfusion with minimal conditioning led to stable lymphoid and myeloid macrochimerism, deletion of alloreactive T cells, expansion of regulatory T cells, and long-term allograft survival (>200 days). Translational advanced vascular composite allotransplants with ASCs and low-dose donor BMCs in nonhuman primates can be developed to enhance functional outcomes and eliminate long-term immunosuppression.
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