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10.5966/sctm.2014-0034

http://scihub22266oqcxt.onion/10.5966/sctm.2014-0034
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C4250205!4250205!25368376
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suck abstract from ncbi


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pmid25368376      Stem+Cells+Transl+Med 2014 ; 3 (12): 1456-66
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  • NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine #MMPMID25368376
  • Dong Y; Long T; Wang C; Mirando AJ; Chen J; O?Keefe RJ; Hilton MJ
  • Stem Cells Transl Med 2014[Dec]; 3 (12): 1456-66 PMID25368376show ga
  • This work examines a novel biological method that entails selection of human bone marrow-derived stromal/stem cells (BMSCs) based on NOTCH2 expression and activation of the NOTCH signaling pathway in cultured BMSCs via a tissue culture plate coated with recombinant human JAGGED1 (JAG1) ligand. We demonstrate that transient JAG1-mediated NOTCH signaling promotes human BMSC maintenance and expansion while increasing their skeletogenic differentiation capacity, both ex vivo and in vivo.
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