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10.1038/nrm3877

http://scihub22266oqcxt.onion/10.1038/nrm3877
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C4250044!4250044!25237825
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suck abstract from ncbi


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pmid25237825      Nat+Rev+Mol+Cell+Biol 2014 ; 15 (10): 634-46
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  • Mitochondrial dynamics and inheritance during cell division, development and disease #MMPMID25237825
  • Mishra P; Chan DC
  • Nat Rev Mol Cell Biol 2014[Oct]; 15 (10): 634-46 PMID25237825show ga
  • During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with other organelles, particularly in their interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features ? including their own genome and a maternal mode of germline transmission ? that place additional demands on this process. We discuss the mechanisms regulating mitochondrial segregation during cell division, oogenesis, fertilization and tissue development. The mechanisms that ensure the integrity of these organelles and their DNA include fusion-fission dynamics, organelle transport, mitophagy, and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.
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