Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cell.2014.05.045 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.05.045 C4249939!4249939!25083868     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 158 (3): 564-78 Nephropedia Template TP {{tp|p=25083868|t=2014. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy |pdf=|usr=}}{{25083868}} gab.com Text The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25083868 #FOAvip Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator Heat-Shock Factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy. HSF1 drives a transcriptional program in CAFs that complements, yet is completely different from, the program it drives in adjacent cancer cells. This CAF program is uniquely structured to support the malignant potential of cancer cells in a non-cell-autonomous way. Two central stromal signaling molecules?TGF? and stromal-derived factor 1 (SDF1) ? play a critical role. In early stage breast and lung cancer, high stromal HSF1 activation is strongly associated with poor patient outcome. Thus, tumors co-opt the ancient survival functions of HSF1 to orchestrate malignancy in both cell-autonomous and non-cell-autonomous ways, with far-reaching therapeutic implications. Twit Text FOAVip The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25083868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25083868 #FOAvip English Wikipedia <ref>{{Cite pmid|25083868}}</ref> The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy #MMPMID25083868 Scherz-Shouval R; Santagata S; Mendillo ML; Sholl LM; Ben-Aharon I; Beck AH; Dias-Santagata D; Koeva M; Stemmer SM; Whitesell L; Lindquist S Cell 2014[Jul]; 158 (3): 564-78 PMID25083868show ga Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator Heat-Shock Factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy. HSF1 drives a transcriptional program in CAFs that complements, yet is completely different from, the program it drives in adjacent cancer cells. This CAF program is uniquely structured to support the malignant potential of cancer cells in a non-cell-autonomous way. Two central stromal signaling molecules?TGF? and stromal-derived factor 1 (SDF1) ? play a critical role. In early stage breast and lung cancer, high stromal HSF1 activation is strongly associated with poor patient outcome. Thus, tumors co-opt the ancient survival functions of HSF1 to orchestrate malignancy in both cell-autonomous and non-cell-autonomous ways, with far-reaching therapeutic implications. äThe reprogramming of tumor stroma by HSF1 is a potent enabler of malig(epmc).pdf DeepDyve Pubget Overpricing