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10.1128/IAI.02487-14 http://scihub22266oqcxt.onion/10.1128/IAI.02487-14 C4249293!4249293 !25287922     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25287922 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin |pdf=|usr=}}{{25287922 }} gab.com Text Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=25287922 #FOAvip The adenylate cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAMP). Since ACT kills macrophages rapidly and potently, we asked whether ACT would also kill neutrophils. In fact, ACT prolongs the neutrophil life span by inhibiting constitutive apoptosis and preventing apoptosis induced by exposure to live B. pertussis. Imaging of B. pertussis-exposed neutrophils revealed that B. pertussis lacking ACT induces formation of neutrophil extracellular traps (NETs), whereas wild-type B. pertussis does not, suggesting that ACT suppresses NET formation. Indeed, ACT inhibits formation of NETs by generating cAMP and consequently inhibiting the oxidative burst. Convalescent-phase serum from humans following clinical pertussis blocks the ACT-mediated suppression of NET formation. These studies provide novel insight into the phagocyte impotence caused by ACT, which not only impairs neutrophil function but also inhibits death of neutrophils by apoptosis and NETosis. Twit Text FOAVip Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=25287922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25287922 #FOAvip English Wikipedia <ref>{{Cite pmid|25287922 }}</ref> Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin #MMPMID25287922 Eby JC ; Gray MC ; Hewlett EL Infect Immun 2014[Dec]; 82 (12 ): 5256-69 PMID25287922 show ga The adenylate cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAMP). Since ACT kills macrophages rapidly and potently, we asked whether ACT would also kill neutrophils. In fact, ACT prolongs the neutrophil life span by inhibiting constitutive apoptosis and preventing apoptosis induced by exposure to live B. pertussis. Imaging of B. pertussis-exposed neutrophils revealed that B. pertussis lacking ACT induces formation of neutrophil extracellular traps (NETs), whereas wild-type B. pertussis does not, suggesting that ACT suppresses NET formation. Indeed, ACT inhibits formation of NETs by generating cAMP and consequently inhibiting the oxidative burst. Convalescent-phase serum from humans following clinical pertussis blocks the ACT-mediated suppression of NET formation. These studies provide novel insight into the phagocyte impotence caused by ACT, which not only impairs neutrophil function but also inhibits death of neutrophils by apoptosis and NETosis. |*Apoptosis [MESH] |*Host-Pathogen Interactions [MESH] |Adenylate Cyclase Toxin/*metabolism [MESH] |Bordetella pertussis/*immunology [MESH] |Cells, Cultured [MESH] |Cyclic AMP/*metabolism [MESH] |Extracellular Traps/*metabolism [MESH] |Humans [MESH]Cyclic AMP-mediated suppression of neutrophil extracellular trap forma(epmc).pdf DeepDyve Pubget Overpricing