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10.1101/gad.249763.114 http://scihub22266oqcxt.onion/10.1101/gad.249763.114 C4248294!4248294 !25452274     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25452274 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2014 ; 28 (23 ): 2636-51 Nephropedia Template TP {{tp|p=25452274 |t=2014. Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development |pdf=|usr=}}{{25452274 }} gab.com Text Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25452274 #FOAvip In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth. It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability. Twit Text FOAVip Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25452274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25452274 #FOAvip English Wikipedia <ref>{{Cite pmid|25452274 }}</ref> Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development #MMPMID25452274 Rodenfels J ; Lavrynenko O ; Ayciriex S ; Sampaio JL ; Carvalho M ; Shevchenko A ; Eaton S Genes Dev 2014[Dec]; 28 (23 ): 2636-51 PMID25452274 show ga In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth. It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability. |Animals [MESH] |Drosophila melanogaster/*growth & development/metabolism [MESH] |Hedgehog Proteins/*blood/metabolism [MESH] |Intestinal Mucosa/metabolism [MESH] |Larva [MESH]Production of systemically circulating Hedgehog by the intestine coupl(epmc).pdf DeepDyve Pubget Overpricing