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10.1089/dna.2014.2639 http://scihub22266oqcxt.onion/10.1089/dna.2014.2639 C4248255!4248255!25188736     free     free     free       DNA+Cell+Biol 2014 ; 33 (12): 823-9 Nephropedia Template TP {{tp|p=25188736|t=2014. The Unexplored Roles of Human Serum IgA |pdf=|usr=}}{{25188736}} gab.com Text The Unexplored Roles of Human Serum IgA JO: DNA Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25188736 #FOAvip The roles of human serum IgA, in contrast to that of mucosal IgA, are relatively unexplored. Previous studies have shown that IgA mediates either pro- or anti-inflammatory effects in innate immune cells. Serum IgA has been shown to interact with many proteins and glycoproteins of which the functions and mechanisms are not fully characterized. Here, we present fresh perspectives into the roles of serum IgA, describing novel IgA?protein interactions, the importance of its glycosylation status in normal functions, and the plausible role of IgA as a driver and regulator of autoimmune diseases/immune overactivation. Other potential roles, including the regulation of cytokines, effector cell function, and homeostasis, are considered in view of the maintenance of immune function. We anticipate future research to uncover new anti-inflammatory or pro-inflammatory roles of human serum IgA in immune functions and dysfunctions, with implications on systemic lupus erythematosus (SLE). Twit Text FOAVip The Unexplored Roles of Human Serum IgA ????DNA Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25188736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25188736 #FOAvip English Wikipedia <ref>{{Cite pmid|25188736}}</ref> The Unexplored Roles of Human Serum IgA #MMPMID25188736 Leong KW; Ding JL DNA Cell Biol 2014[Dec]; 33 (12): 823-9 PMID25188736show ga The roles of human serum IgA, in contrast to that of mucosal IgA, are relatively unexplored. Previous studies have shown that IgA mediates either pro- or anti-inflammatory effects in innate immune cells. Serum IgA has been shown to interact with many proteins and glycoproteins of which the functions and mechanisms are not fully characterized. Here, we present fresh perspectives into the roles of serum IgA, describing novel IgA?protein interactions, the importance of its glycosylation status in normal functions, and the plausible role of IgA as a driver and regulator of autoimmune diseases/immune overactivation. Other potential roles, including the regulation of cytokines, effector cell function, and homeostasis, are considered in view of the maintenance of immune function. We anticipate future research to uncover new anti-inflammatory or pro-inflammatory roles of human serum IgA in immune functions and dysfunctions, with implications on systemic lupus erythematosus (SLE). äThe Unexplored Roles of Human Serum IgA (epmc).pdf DeepDyve Pubget Overpricing