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10.1038/ki.2014.326 http://scihub22266oqcxt.onion/10.1038/ki.2014.326 C4246419!4246419!25427084     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2014 ; 86 (6): 1081-3 Nephropedia Template TP {{tp|p=25427084|t=2014. Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome |pdf=|usr=}}{{25427084}} gab.com Text Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=25427084 #FOAvip Next generation sequencing applied to families with glomerular disease has been instrumental in identifying new genes and pathways involved in podocyte homeostasis. Malone et al. performed sequencing on 70 families with FSGS and discovered that 10% had variants in surprising ?old? genes, COL4A3 and COL4A4, which are involved in Alport syndrome and thin basement membrane nephropathy. These data show that a subset of renal manifestations associated with COL4A3 or COL4A4 variants cannot be distinguished from FSGS by clinical data or by histopathology. Thus, a diagnosis of FSGS may sometimes fall within the spectrum of Alport syndrome. Twit Text FOAVip Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=25427084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25427084 #FOAvip English Wikipedia <ref>{{Cite pmid|25427084}}</ref> Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome #MMPMID25427084 Miner JH Kidney Int 2014[Dec]; 86 (6): 1081-3 PMID25427084show ga Next generation sequencing applied to families with glomerular disease has been instrumental in identifying new genes and pathways involved in podocyte homeostasis. Malone et al. performed sequencing on 70 families with FSGS and discovered that 10% had variants in surprising ?old? genes, COL4A3 and COL4A4, which are involved in Alport syndrome and thin basement membrane nephropathy. These data show that a subset of renal manifestations associated with COL4A3 or COL4A4 variants cannot be distinguished from FSGS by clinical data or by histopathology. Thus, a diagnosis of FSGS may sometimes fall within the spectrum of Alport syndrome. äPathology versus molecular genetics: (re)defining the spectrum of Alpo(epmc).pdf DeepDyve Pubget Overpricing