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10.1007/s11357-014-9733-1 http://scihub22266oqcxt.onion/10.1007/s11357-014-9733-1 C4245403!4245403 !25427998     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25427998 &cmd=llinks): Failed to open stream: HTTP request failed! 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FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs |pdf=|usr=}}{{25427998 }} gab.com Text FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs JO: Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=25427998 #FOAvip Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n?=?175, 144 women) and healthy controls (n?=?347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P???0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P?=?0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P?=?0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling. Twit Text FOAVip FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs ????Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=25427998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25427998 #FOAvip English Wikipedia <ref>{{Cite pmid|25427998 }}</ref> FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs #MMPMID25427998 Sanchis-Gomar F ; Garatachea N ; He ZH ; Pareja-Galeano H ; Fuku N ; Tian Y ; Arai Y ; Abe Y ; Murakami H ; Miyachi M ; Yvert T ; Santiago C ; Venturini L ; Fiuza-Luces C ; Santos-Lozano A ; Rodríguez-Romo G ; Ricevuti G ; Hirose N ; Emanuele E ; Lucia A Age (Dordr) 2014[]; 36 (6 ): 9733 PMID25427998 show ga Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n?=?175, 144 women) and healthy controls (n?=?347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P???0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P?=?0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P?=?0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling. |*Gene Frequency [MESH] |*Polymorphism, Single Nucleotide [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Aging/genetics [MESH] |Cohort Studies [MESH] |Confidence Intervals [MESH] |Female [MESH] |Fibronectins/*genetics [MESH] |Genotype [MESH] |Humans [MESH] |Italy [MESH] |Japan [MESH] |Logistic Models [MESH] |Longevity/*genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Odds Ratio [MESH] |Reference Values [MESH] |Spain [MESH]FNDC5 (irisin) gene and exceptional longevity: a functional replicatio(epmc).pdf DeepDyve Pubget Overpricing