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10.1038/labinvest.2014.126 http://scihub22266oqcxt.onion/10.1038/labinvest.2014.126 C4245361!4245361 !25365203     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25365203 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Lab+Invest 2014 ; 94 (12 ): 1312-25 Nephropedia Template TP {{tp|p=25365203 |t=2014. Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness |pdf=|usr=}}{{25365203 }} gab.com Text Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=25365203 #FOAvip Cigarette smoking enhances oxidative stress and airway inflammation in asthma, the mechanisms of which are largely unknown. Myeloid-derived regulatory cells (MDRC) are free radical producing immature myeloid cells with immunoregulatory properties that have recently been demonstrated as critical regulators of allergic airway inflammation. NO (nitric oxide)-producing immunosuppressive MDRC suppress T-cell proliferation and airway-hyper responsiveness (AHR), while the O2(?-) (superoxide)-producing MDRC are proinflammatory. We hypothesized that cigarette smoke (CS) exposure may impact MDRC function and contribute to exacerbations in asthma. Exposure of bone marrow (BM)-derived NO-producing MDRC to CS reduced the production of NO and its metabolites and inhibited their potential to suppress T-cell proliferation. Production of immunoregulatory cytokine IL-10 was significantly inhibited, while proinflammatory cytokines IL-6, IL-1?, TNF-? and IL-33 were enhanced in CS-exposed BM-MDRC. Additionally, CS exposure increased NF-?B activation and induced BM-MDRC-mediated production of O2(?-), via NF-?B-dependent pathway. Intratracheal transfer of smoke-exposed MDRC-producing proinflammatory cytokines increased NF-?B activation, reactive oxygen species and mucin production in vivo and exacerbated AHR in C57BL/6 mice, mice deficient in Type I IFNR and MyD88, both with reduced numbers of endogenous MDRC. Thus CS exposure modulates MDRC function and contributes to asthma exacerbation and identifies MDRC as potential targets for asthma therapy. Twit Text FOAVip Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=25365203 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25365203 #FOAvip English Wikipedia <ref>{{Cite pmid|25365203 }}</ref> Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness #MMPMID25365203 Wang Y ; Jin TH ; Farhana A ; Freeman J ; Estell K ; Zmijewski JW ; Gaggar A ; Thannickal VJ ; Schwiebert LM ; Steyn AJ ; Deshane JS Lab Invest 2014[Dec]; 94 (12 ): 1312-25 PMID25365203 show ga Cigarette smoking enhances oxidative stress and airway inflammation in asthma, the mechanisms of which are largely unknown. Myeloid-derived regulatory cells (MDRC) are free radical producing immature myeloid cells with immunoregulatory properties that have recently been demonstrated as critical regulators of allergic airway inflammation. NO (nitric oxide)-producing immunosuppressive MDRC suppress T-cell proliferation and airway-hyper responsiveness (AHR), while the O2(?-) (superoxide)-producing MDRC are proinflammatory. We hypothesized that cigarette smoke (CS) exposure may impact MDRC function and contribute to exacerbations in asthma. Exposure of bone marrow (BM)-derived NO-producing MDRC to CS reduced the production of NO and its metabolites and inhibited their potential to suppress T-cell proliferation. Production of immunoregulatory cytokine IL-10 was significantly inhibited, while proinflammatory cytokines IL-6, IL-1?, TNF-? and IL-33 were enhanced in CS-exposed BM-MDRC. Additionally, CS exposure increased NF-?B activation and induced BM-MDRC-mediated production of O2(?-), via NF-?B-dependent pathway. Intratracheal transfer of smoke-exposed MDRC-producing proinflammatory cytokines increased NF-?B activation, reactive oxygen species and mucin production in vivo and exacerbated AHR in C57BL/6 mice, mice deficient in Type I IFNR and MyD88, both with reduced numbers of endogenous MDRC. Thus CS exposure modulates MDRC function and contributes to asthma exacerbation and identifies MDRC as potential targets for asthma therapy. |Adoptive Transfer [MESH] |Animals [MESH] |Bone Marrow Cells/physiology [MESH] |Bronchial Hyperreactivity/*etiology [MESH] |Cells, Cultured [MESH] |Interleukin-33 [MESH] |Interleukins/biosynthesis [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myeloid Cells/*physiology [MESH] |NF-kappa B/physiology [MESH] |Nicotiana/*adverse effects [MESH] |Nitric Oxide/biosynthesis [MESH] |Reactive Oxygen Species/metabolism [MESH]Exposure to cigarette smoke impacts myeloid-derived regulatory cell fu(epmc).pdf DeepDyve Pubget Overpricing