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10.1016/j.cmet.2014.09.001 http://scihub22266oqcxt.onion/10.1016/j.cmet.2014.09.001 C4245205!4245205 !25295787     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25295787 &cmd=llinks): Failed to open stream: HTTP request failed! 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Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy |pdf=|usr=}}{{25295787 }} gab.com Text Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25295787 #FOAvip Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism. Of the various inputs to mTORC1, the amino acid sensing pathway is among the most potent. Based upon transcriptome analysis of neurons subjected to nutrient deprivation, we identified let-7 microRNA as capable of promoting neuronal autophagy. We found that let-7 activates autophagy by coordinately downregulating the amino acid sensing pathway to prevent mTORC1 activation. Let-7 induced autophagy in the brain to eliminate protein aggregates, establishing its physiological relevance for in vivo autophagy modulation. Moreover, peripheral delivery of let-7 anti-miR repressed autophagy in muscle and white fat, suggesting that let-7 autophagy regulation extends beyond CNS. Hence, let-7 plays a central role in nutrient homeostasis and proteostasis regulation in higher organisms. Twit Text FOAVip Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25295787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25295787 #FOAvip English Wikipedia <ref>{{Cite pmid|25295787 }}</ref> Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy #MMPMID25295787 Dubinsky AN ; Dastidar SG ; Hsu CL ; Zahra R ; Djakovic SN ; Duarte S ; Esau CC ; Spencer B ; Ashe TD ; Fischer KM ; MacKenna DA ; Sopher BL ; Masliah E ; Gaasterland T ; Chau BN ; Pereira de Almeida L ; Morrison BE ; La Spada AR Cell Metab 2014[Oct]; 20 (4 ): 626-38 PMID25295787 show ga Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism. Of the various inputs to mTORC1, the amino acid sensing pathway is among the most potent. Based upon transcriptome analysis of neurons subjected to nutrient deprivation, we identified let-7 microRNA as capable of promoting neuronal autophagy. We found that let-7 activates autophagy by coordinately downregulating the amino acid sensing pathway to prevent mTORC1 activation. Let-7 induced autophagy in the brain to eliminate protein aggregates, establishing its physiological relevance for in vivo autophagy modulation. Moreover, peripheral delivery of let-7 anti-miR repressed autophagy in muscle and white fat, suggesting that let-7 autophagy regulation extends beyond CNS. Hence, let-7 plays a central role in nutrient homeostasis and proteostasis regulation in higher organisms. |*Autophagy [MESH] |Adipose Tissue, White/metabolism [MESH] |Amino Acids/*metabolism [MESH] |Animals [MESH] |Base Sequence [MESH] |Brain/metabolism [MESH] |Cells, Cultured [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Insulin/metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |MicroRNAs/antagonists & inhibitors/*metabolism [MESH] |Monomeric GTP-Binding Proteins/antagonists & inhibitors/genetics/metabolism [MESH] |Multiprotein Complexes/*metabolism [MESH] |Muscle, Skeletal/metabolism [MESH] |Neurons/cytology/metabolism [MESH] |Protein Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism [MESH] |RNA Interference [MESH] |Sequence Alignment [MESH] |Signal Transduction [MESH]Let-7 coordinately suppresses components of the amino acid sensing pat(epmc).pdf DeepDyve Pubget Overpricing