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10.1002/pro.2510 http://scihub22266oqcxt.onion/10.1002/pro.2510 C4243990!4243990!24963990     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Sci 2014 ; 23 (9): 1161-4 Nephropedia Template TP {{tp|p=24963990|t=2014. An osmolyte mitigates the destabilizing effect of protein crowding |pdf=|usr=}}{{24963990}} gab.com Text An osmolyte mitigates the destabilizing effect of protein crowding JO: Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=24963990 #FOAvip Most theories predict that macromolecular crowding stabilizes globular proteins, but recent studies show that weak attractive interactions can result in crowding-induced destabilization. Osmolytes are ubiquitous in biology and help protect cells against stress. Given that dehydration stress adds to the crowded nature of the cytoplasm, we speculated that cells might use osmolytes to overcome the destabilization caused by the increased weak interactions that accompany desiccation. We used NMR-detected amide proton exchange experiments to measure the stability of the test protein chymotrypsin inhibitor 2 under physiologically relevant crowded conditions in the presence and absence of the osmolyte glycine betaine. The osmolyte overcame the destabilizing effect of the cytosol. This result provides a physiologically relevant explanation for the accumulation of osmolytes by dehydration-stressed cells. Twit Text FOAVip An osmolyte mitigates the destabilizing effect of protein crowding ????Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=24963990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24963990 #FOAvip English Wikipedia <ref>{{Cite pmid|24963990}}</ref> An osmolyte mitigates the destabilizing effect of protein crowding #MMPMID24963990 Sarkar M; Pielak GJ Protein Sci 2014[Sep]; 23 (9): 1161-4 PMID24963990show ga Most theories predict that macromolecular crowding stabilizes globular proteins, but recent studies show that weak attractive interactions can result in crowding-induced destabilization. Osmolytes are ubiquitous in biology and help protect cells against stress. Given that dehydration stress adds to the crowded nature of the cytoplasm, we speculated that cells might use osmolytes to overcome the destabilization caused by the increased weak interactions that accompany desiccation. We used NMR-detected amide proton exchange experiments to measure the stability of the test protein chymotrypsin inhibitor 2 under physiologically relevant crowded conditions in the presence and absence of the osmolyte glycine betaine. The osmolyte overcame the destabilizing effect of the cytosol. This result provides a physiologically relevant explanation for the accumulation of osmolytes by dehydration-stressed cells. äAn osmolyte mitigates the destabilizing effect of protein crowding (epmc).pdf DeepDyve Pubget Overpricing