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10.1681/ASN.2013101068 http://scihub22266oqcxt.onion/10.1681/ASN.2013101068 C4243349!4243349!24854279     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2014 ; 25 (12): 2835-46 Nephropedia Template TP {{tp|p=24854279|t=2014. Autophagy Regulates TGF-? Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction |pdf=|usr=}}{{24854279}} gab.com Text Autophagy Regulates TGF- Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24854279 #FOAvip Autophagy is an evolutionarily conserved process that cells use to degrade and recycle cellular proteins and remove damaged organelles. During the past decade, there has been a growing interest in defining the basic cellular mechanism of autophagy and its roles in health and disease. However, the functional role of autophagy in kidney fibrosis remains poorly understood. Here, using GFP-LC3 transgenic mice, we show that autophagy is induced in renal tubular epithelial cells (RTECs) of obstructed kidneys after unilateral ureteral obstruction (UUO). Deletion of LC3B (LC3?/? mice) resulted in increased collagen deposition and increased mature profibrotic factor TGF-? levels in obstructed kidneys. Beclin 1 heterozygous (beclin 1+/?) mice also displayed increased collagen deposition in the obstructed kidneys after UUO. We also show that TGF-?1 induces autophagy in primary mouse RTECs and human renal proximal tubular epithelial (HK-2) cells. LC3 deficiency resulted in increased levels of mature TGF-? in primary RTECs. Under conditions of TGF-?1 stimulation and autoinduction, inhibition of autolysosomal protein degradation by bafilomycin A1 increased mature TGF-? protein levels without alterations in TGF-?1 mRNA. These data suggest a novel intracellular mechanism by which mature TGF-?1 protein levels may be regulated in RTECs through autophagic degradation, which suppresses kidney fibrosis induced by UUO. The dual functions of TGF-?1, as an inducer of TGF-?1 autoinduction and an inducer of autophagy and TGF-? degradation, underscore the multifunctionality of TGF-?1. Twit Text FOAVip Autophagy Regulates TGF- Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24854279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24854279 #FOAvip English Wikipedia <ref>{{Cite pmid|24854279}}</ref> Autophagy Regulates TGF-? Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction #MMPMID24854279 Ding Y; Kim Sl; Lee SY; Koo JK; Wang Z; Choi ME J Am Soc Nephrol 2014[Dec]; 25 (12): 2835-46 PMID24854279show ga Autophagy is an evolutionarily conserved process that cells use to degrade and recycle cellular proteins and remove damaged organelles. During the past decade, there has been a growing interest in defining the basic cellular mechanism of autophagy and its roles in health and disease. However, the functional role of autophagy in kidney fibrosis remains poorly understood. Here, using GFP-LC3 transgenic mice, we show that autophagy is induced in renal tubular epithelial cells (RTECs) of obstructed kidneys after unilateral ureteral obstruction (UUO). Deletion of LC3B (LC3?/? mice) resulted in increased collagen deposition and increased mature profibrotic factor TGF-? levels in obstructed kidneys. Beclin 1 heterozygous (beclin 1+/?) mice also displayed increased collagen deposition in the obstructed kidneys after UUO. We also show that TGF-?1 induces autophagy in primary mouse RTECs and human renal proximal tubular epithelial (HK-2) cells. LC3 deficiency resulted in increased levels of mature TGF-? in primary RTECs. Under conditions of TGF-?1 stimulation and autoinduction, inhibition of autolysosomal protein degradation by bafilomycin A1 increased mature TGF-? protein levels without alterations in TGF-?1 mRNA. These data suggest a novel intracellular mechanism by which mature TGF-?1 protein levels may be regulated in RTECs through autophagic degradation, which suppresses kidney fibrosis induced by UUO. The dual functions of TGF-?1, as an inducer of TGF-?1 autoinduction and an inducer of autophagy and TGF-? degradation, underscore the multifunctionality of TGF-?1. äAutophagy Regulates TGF-? Expression and Suppresses Kidney Fibrosis In(epmc).pdf DeepDyve Pubget Overpricing