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10.1002/mc.22139 http://scihub22266oqcxt.onion/10.1002/mc.22139 C4242796!4242796 !24700667     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24700667 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Carcinog 2015 ; 54 (9 ): 751-60 Nephropedia Template TP {{tp|p=24700667 |t=2015. Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling |pdf=|usr=}}{{24700667 }} gab.com Text Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling JO: Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=24700667 #FOAvip Phosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway, which contributes to the progression and invasiveness of prostate cancer. Furthermore, the PTEN/PI3-K/Akt and Ras/MAPK pathways cooperate to promote the epithelial-mesenchymal transition (EMT) and metastasis initiated from prostate stem/progenitor cells. For these reasons, the PTEN/PI3-K/Akt pathway is considered as an attractive target for both chemoprevention and chemotherapy. Herein we report that eupafolin, a natural compound found in common sage, inhibited proliferation of prostate cancer cells. Protein content analysis indicated that phosphorylation of Akt and its downstream kinases was inhibited by eupafolin treatment. Pull-down assay and in vitro kinase assay results indicated that eupafolin could bind with PI3-K and attenuate its kinase activity. Eupafolin also exhibited tumor suppressive effects in vivo in an athymic nude mouse model. Overall, these results suggested that eupafolin exerts antitumor effects by targeting PI3-K. Twit Text FOAVip Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling ????Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=24700667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24700667 #FOAvip English Wikipedia <ref>{{Cite pmid|24700667 }}</ref> Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling #MMPMID24700667 Liu K ; Park C ; Chen H ; Hwang J ; Thimmegowda NR ; Bae EY ; Lee KW ; Kim HG ; Liu H ; Soung NK ; Peng C ; Jang JH ; Kim KE ; Ahn JS ; Bode AM ; Dong Z ; Kim BY ; Dong Z Mol Carcinog 2015[Sep]; 54 (9 ): 751-60 PMID24700667 show ga Phosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway, which contributes to the progression and invasiveness of prostate cancer. Furthermore, the PTEN/PI3-K/Akt and Ras/MAPK pathways cooperate to promote the epithelial-mesenchymal transition (EMT) and metastasis initiated from prostate stem/progenitor cells. For these reasons, the PTEN/PI3-K/Akt pathway is considered as an attractive target for both chemoprevention and chemotherapy. Herein we report that eupafolin, a natural compound found in common sage, inhibited proliferation of prostate cancer cells. Protein content analysis indicated that phosphorylation of Akt and its downstream kinases was inhibited by eupafolin treatment. Pull-down assay and in vitro kinase assay results indicated that eupafolin could bind with PI3-K and attenuate its kinase activity. Eupafolin also exhibited tumor suppressive effects in vivo in an athymic nude mouse model. Overall, these results suggested that eupafolin exerts antitumor effects by targeting PI3-K. |Animals [MESH] |Antineoplastic Agents, Phytogenic/*therapeutic use [MESH] |Cell Proliferation/drug effects [MESH] |Flavones/*therapeutic use [MESH] |Humans [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Models, Molecular [MESH] |Phosphatidylinositol 3-Kinases/*metabolism [MESH] |Prostate/*drug effects/metabolism/pathology [MESH] |Prostatic Neoplasms/*drug therapy/metabolism/pathology [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH]Eupafolin suppresses prostate cancer by targeting phosphatidylinositol(epmc).pdf DeepDyve Pubget Overpricing