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Automating the processing steps for obtaining bone tissue-engineered substitutes:
from imaging tools to bioreactors
#MMPMID24673688
Costa PF
; Martins A
; Neves NM
; Gomes ME
; Reis RL
Tissue Eng Part B Rev
2014[Dec]; 20
(6
): 567-77
PMID24673688
show ga
Bone diseases and injuries are highly incapacitating and result in a high demand
for tissue substitutes with specific biomechanical and structural features.
Tissue engineering has already proven to be effective in regenerating bone
tissue, but has not yet been able to become an economically viable solution due
to the complexity of the tissue, which is very difficult to be replicated,
eventually requiring the utilization of highly labor-intensive processes. Process
automation is seen as the solution for mass production of cellularized bone
tissue substitutes at an affordable cost by being able to reduce human
intervention as well as reducing product variability. The combination of tools
such as medical imaging, computer-aided fabrication, and bioreactor technologies,
which are currently used in tissue engineering, shows the potential to generate
automated production ecosystems, which will, in turn, enable the generation of
commercially available products with widespread clinical application.
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