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10.1016/j.fob.2014.10.012 http://scihub22266oqcxt.onion/10.1016/j.fob.2014.10.012 C4241534!4241534 !25426416     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25426416 &cmd=llinks): Failed to open stream: HTTP request failed! 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MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines |pdf=|usr=}}{{25426416 }} gab.com Text MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=25426416 #FOAvip Neuroblastoma is an extra-cranial solid cancer in children. MYCN gene amplification is a prognostic indicator of poor outcome in neuroblastoma. Recent studies have shown that the multiple steps involved in cell migration are dependent on the availability of intracellular calcium (Ca(2+)). Although significant advances have been made in understanding the role of Ca(2+) during migration, little has been achieved towards understanding its impact on the progression of diseases such as cancer. Interestingly, previous studies showed that cancer cell migration is regulated by TRPM7, a calcium-permeable ion channel. The objective of the current study was to elucidate the mechanism by which MycN promotes NB cell migration and the mechanism regulating TRPM7 expression. The results showed that MycN increased TRPM7 expression, induced TRPM7 channel activity, increased intracellular Ca(2+) signaling, and promoted cell migration in NB cells. The results also showed that inhibition or down-regulation of ornithine decarboxylase (ODC) inhibited TRPM7 expression, a process that was reversed by spermidine. Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines. Twit Text FOAVip MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=25426416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25426416 #FOAvip English Wikipedia <ref>{{Cite pmid|25426416 }}</ref> MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines #MMPMID25426416 Lange I ; Koomoa DL FEBS Open Bio 2014[]; 4 (ä): 966-75 PMID25426416 show ga Neuroblastoma is an extra-cranial solid cancer in children. MYCN gene amplification is a prognostic indicator of poor outcome in neuroblastoma. Recent studies have shown that the multiple steps involved in cell migration are dependent on the availability of intracellular calcium (Ca(2+)). Although significant advances have been made in understanding the role of Ca(2+) during migration, little has been achieved towards understanding its impact on the progression of diseases such as cancer. Interestingly, previous studies showed that cancer cell migration is regulated by TRPM7, a calcium-permeable ion channel. The objective of the current study was to elucidate the mechanism by which MycN promotes NB cell migration and the mechanism regulating TRPM7 expression. The results showed that MycN increased TRPM7 expression, induced TRPM7 channel activity, increased intracellular Ca(2+) signaling, and promoted cell migration in NB cells. The results also showed that inhibition or down-regulation of ornithine decarboxylase (ODC) inhibited TRPM7 expression, a process that was reversed by spermidine. Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines. äMycN promotes TRPM7 expression and cell migration in neuroblastoma thr(epmc).pdf DeepDyve Pubget Overpricing