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10.1111/ijcp.12466

http://scihub22266oqcxt.onion/10.1111/ijcp.12466
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C4241393!4241393!24853089
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suck abstract from ncbi


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pmid24853089      Int+J+Clin+Pract 2014 ; 68 (12): 1508-13
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  • Development of SLE among ?Potential SLE? Patients Seen in Consultation: Long-Term Follow-Up #MMPMID24853089
  • Al Daabil M; Massarotti EM; Fine A; Tsao H; Ho P; Schur PH; Bermas BL; Costenbader KH
  • Int J Clin Pract 2014[Dec]; 68 (12): 1508-13 PMID24853089show ga
  • Objective: To identify factors associated with development of systemic lupus erythematosus (SLE) among patients evaluated at a tertiary care Lupus Center for potential SLE Methods: We identified patients first seen at the Brigham and Women's Hospital Lupus Center between January 1, 1992 and December 31, 2012 and thought to have potential SLE by a board certified rheumatologist. All had 1-3 SLE ACR criteria at initial visit and >2 follow-up visits ? 3 months apart. We reviewed medical records through May 15, 2013 for: SLE signs and symptoms, autoimmune serologies, prescriptions, and diagnoses by board certified rheumatologists. Bivariable analyses and multivariable logistic regression models were used to identify independent predictors of developing SLE. Results: 264 patients met inclusion criteria. At initial visit, mean age was 39.2 (SD 12.4) years, 94% were female and 67% white. Mean number of SLE ACR criteria was 2.7 (SD 1.0) and 88% were antinuclear antibody (ANA) positive at initial consultation. Mean follow-up time was 6.3 (SD 4.3) years and 67% were prescribed hydroxychloroquine in follow-up. At most recent visit, 56 (21%) had been diagnosed with SLE; 47 (18%) were thought not to have SLE; and 161 (61%) were still considered to have potential SLE. In multivariable regression models, oral ulcers (OR 2.40, 95%CI 1.03-5.58), anti-dsDNA (OR 2.59, 95% CI 1.25-5.35) and baseline proteinuria or cellular casts (OR 16.20, 95%CI 1.63-161.02) were independent predictors of developing SLE. The most common other final diagnoses included fibromyalgia, Sjögren's syndrome, mixed connective tissue disease and cutaneous lupus. Conclusion: Among patients with potential SLE at initial consultation, 21% were diagnosed with definite SLE within 6.3 years. Oral ulcers, anti-dsDNA and proteinuria or cellular casts were independent predictors of developing definite SLE. A better means of accurately identifying those who will develop SLE among those presenting with potential disease is necessary.
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