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10.4049/jimmunol.1400852 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400852 C4241261!4241261!25210122     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (8): 4178-87 Nephropedia Template TP {{tp|p=25210122|t=2014. Eosinophil-derived IL-10 supports chronic nematode infection1 |pdf=|usr=}}{{25210122}} gab.com Text Eosinophil-derived IL-10 supports chronic nematode infection1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25210122 #FOAvip Eosinophilia is a feature of the host immune response that distinguishes parasitic worms from other pathogens, yet a discrete function for eosinophils in worm infection has been elusive. The aim of this study was to clarify the mechanism(s) underlying the striking and unexpected observation that eosinophils protect intracellular, muscle-stage Trichinella spiralis larvae against NO-mediated killing. Our findings indicate that eosinophils are specifically recruited to sites of infection at the earliest stage of muscle infection, consistent with a local response to injury. Early recruitment is essential for larval survival. By producing IL-10 at the initiation of infection, eosinophils expand IL-10+ myeloid dendritic cells and CD4+ IL-10+ T lymphocytes that inhibit iNOS expression and protect intracellular larvae. The results document a novel immunoregulatory function of eosinophils in helminth infection, in which eosinophil-derived IL-10 drives immune responses that eventually limit local nitric oxide production. In this way, the parasite co-opts an immune response in a way that enhances its own survival. Twit Text FOAVip Eosinophil-derived IL-10 supports chronic nematode infection1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25210122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25210122 #FOAvip English Wikipedia <ref>{{Cite pmid|25210122}}</ref> Eosinophil-derived IL-10 supports chronic nematode infection1 #MMPMID25210122 Huang L; Gebreselassie NG; Gagliardo LF; Ruyechan MC; Lee NA; Lee JJ; Appleton JA J Immunol 2014[Oct]; 193 (8): 4178-87 PMID25210122show ga Eosinophilia is a feature of the host immune response that distinguishes parasitic worms from other pathogens, yet a discrete function for eosinophils in worm infection has been elusive. The aim of this study was to clarify the mechanism(s) underlying the striking and unexpected observation that eosinophils protect intracellular, muscle-stage Trichinella spiralis larvae against NO-mediated killing. Our findings indicate that eosinophils are specifically recruited to sites of infection at the earliest stage of muscle infection, consistent with a local response to injury. Early recruitment is essential for larval survival. By producing IL-10 at the initiation of infection, eosinophils expand IL-10+ myeloid dendritic cells and CD4+ IL-10+ T lymphocytes that inhibit iNOS expression and protect intracellular larvae. The results document a novel immunoregulatory function of eosinophils in helminth infection, in which eosinophil-derived IL-10 drives immune responses that eventually limit local nitric oxide production. In this way, the parasite co-opts an immune response in a way that enhances its own survival. äEosinophil-derived IL-10 supports chronic nematode infection1 (epmc).pdf DeepDyve Pubget Overpricing