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10.4049/jimmunol.1401655 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401655 C4239311!4239311 !25344473     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25344473 &cmd=llinks): Failed to open stream: HTTP request failed! 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T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction |pdf=|usr=}}{{25344473 }} gab.com Text T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25344473 #FOAvip Thymic development requires bidirectional interaction or cross-talk between developing T cells and thymic stromal cells, a relationship that has been best characterized for the interaction between thymocytes and thymic epithelial cells. We have characterized in this article the requirement for similar cross-talk in the maintenance and function of thymic B cells, another population that plays a role in selection of developing thymic T cells. We found that maintenance of thymic B cells is strongly dependent on the presence of mature single-positive thymocytes and on the interactions of these T cells with specific Ag ligand. Maintenance of thymic B cell number is strongly dependent on B cell-autonomous expression of CD40, but not MHC class II, indicating that direct engagement of CD40 on thymic B cells is necessary to support their maintenance and proliferation. Thymic B cells can mediate negative selection of superantigen-specific, self-reactive, single-positive thymocytes, and we show that CD40 expression on B cells is critical for this negative selection. Cross-talk with thymic T cells is thus required to support the thymic B cell population through a pathway that requires cell-autonomous expression of CD40, and that reciprocally functions in negative selection of autoreactive T cells. Twit Text FOAVip T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25344473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25344473 #FOAvip English Wikipedia <ref>{{Cite pmid|25344473 }}</ref> T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction #MMPMID25344473 Fujihara C ; Williams JA ; Watanabe M ; Jeon H ; Sharrow SO ; Hodes RJ J Immunol 2014[Dec]; 193 (11 ): 5534-44 PMID25344473 show ga Thymic development requires bidirectional interaction or cross-talk between developing T cells and thymic stromal cells, a relationship that has been best characterized for the interaction between thymocytes and thymic epithelial cells. We have characterized in this article the requirement for similar cross-talk in the maintenance and function of thymic B cells, another population that plays a role in selection of developing thymic T cells. We found that maintenance of thymic B cells is strongly dependent on the presence of mature single-positive thymocytes and on the interactions of these T cells with specific Ag ligand. Maintenance of thymic B cell number is strongly dependent on B cell-autonomous expression of CD40, but not MHC class II, indicating that direct engagement of CD40 on thymic B cells is necessary to support their maintenance and proliferation. Thymic B cells can mediate negative selection of superantigen-specific, self-reactive, single-positive thymocytes, and we show that CD40 expression on B cells is critical for this negative selection. Cross-talk with thymic T cells is thus required to support the thymic B cell population through a pathway that requires cell-autonomous expression of CD40, and that reciprocally functions in negative selection of autoreactive T cells. |Animals [MESH] |Autoantigens/immunology [MESH] |B-Lymphocytes/*immunology [MESH] |CD40 Antigens/genetics/*metabolism [MESH] |CD40 Ligand/genetics/*metabolism [MESH] |Cell Communication [MESH] |Cell Proliferation [MESH] |Cell Survival [MESH] |Cells, Cultured [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Protein Binding/genetics [MESH] |T-Lymphocytes/*immunology [MESH]T cell-B cell thymic cross-talk: maintenance and function of thymic B (epmc).pdf DeepDyve Pubget Overpricing