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10.1200/JCO.2014.57.2909 http://scihub22266oqcxt.onion/10.1200/JCO.2014.57.2909 C4239303!4239303 !25349290     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25349290 &cmd=llinks): Failed to open stream: HTTP request failed! 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Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial |pdf=|usr=}}{{25349290 }} gab.com Text Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial JO: J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25349290 #FOAvip PURPOSE: Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison with a historical control of patients treated with WBRT without hippocampal avoidance. PATIENTS AND METHODS: Eligible adult patients with brain metastases received HA-WBRT to 30 Gy in 10 fractions. Standardized cognitive function and quality-of-life (QOL) assessments were performed at baseline and 2, 4, and 6 months. The primary end point was the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 4 months. The historical control demonstrated a 30% mean relative decline in HVLT-R DR from baseline to 4 months. To detect a mean relative decline ? 15% in HVLT-R DR after HA-WBRT, 51 analyzable patients were required to ensure 80% statistical power with ? = 0.05. RESULTS: Of 113 patients accrued from March 2011 through November 2012, 42 patients were analyzable at 4 months. Mean relative decline in HVLT-R DR from baseline to 4 months was 7.0% (95% CI, -4.7% to 18.7%), significantly lower in comparison with the historical control (P < .001). No decline in QOL scores was observed. Two grade 3 toxicities and no grade 4 to 5 toxicities were reported. Median survival was 6.8 months. CONCLUSION: Conformal avoidance of the hippocampus during WBRT is associated with preservation of memory and QOL as compared with historical series. Twit Text FOAVip Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial ????J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25349290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25349290 #FOAvip English Wikipedia <ref>{{Cite pmid|25349290 }}</ref> Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial #MMPMID25349290 Gondi V ; Pugh SL ; Tome WA ; Caine C ; Corn B ; Kanner A ; Rowley H ; Kundapur V ; DeNittis A ; Greenspoon JN ; Konski AA ; Bauman GS ; Shah S ; Shi W ; Wendland M ; Kachnic L ; Mehta MP J Clin Oncol 2014[Dec]; 32 (34 ): 3810-6 PMID25349290 show ga PURPOSE: Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison with a historical control of patients treated with WBRT without hippocampal avoidance. PATIENTS AND METHODS: Eligible adult patients with brain metastases received HA-WBRT to 30 Gy in 10 fractions. Standardized cognitive function and quality-of-life (QOL) assessments were performed at baseline and 2, 4, and 6 months. The primary end point was the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 4 months. The historical control demonstrated a 30% mean relative decline in HVLT-R DR from baseline to 4 months. To detect a mean relative decline ? 15% in HVLT-R DR after HA-WBRT, 51 analyzable patients were required to ensure 80% statistical power with ? = 0.05. RESULTS: Of 113 patients accrued from March 2011 through November 2012, 42 patients were analyzable at 4 months. Mean relative decline in HVLT-R DR from baseline to 4 months was 7.0% (95% CI, -4.7% to 18.7%), significantly lower in comparison with the historical control (P < .001). No decline in QOL scores was observed. Two grade 3 toxicities and no grade 4 to 5 toxicities were reported. Median survival was 6.8 months. CONCLUSION: Conformal avoidance of the hippocampus during WBRT is associated with preservation of memory and QOL as compared with historical series. |*Radiotherapy, Intensity-Modulated/adverse effects/mortality [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Brain Neoplasms/mortality/*radiotherapy/*secondary [MESH] |Cognition [MESH] |Cranial Irradiation/adverse effects/*methods/mortality [MESH] |Dose Fractionation, Radiation [MESH] |Female [MESH] |Hippocampus/physiopathology/*radiation effects [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |Memory Disorders/etiology/mortality/physiopathology/*prevention & control/psychology [MESH] |Mental Recall/*radiation effects [MESH] |Middle Aged [MESH] |Neural Stem Cells/*radiation effects [MESH] |Neuropsychological Tests [MESH] |Quality of Life [MESH] |Radiation Injuries/etiology/mortality/physiopathology/*prevention & control/psychology [MESH] |Risk Factors [MESH] |Surveys and Questionnaires [MESH] |Time Factors [MESH]Preservation of memory with conformal avoidance of the hippocampal neu(epmc).pdf DeepDyve Pubget Overpricing