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10.1007/s11046-014-9794-9 http://scihub22266oqcxt.onion/10.1007/s11046-014-9794-9 C4239173!4239173!25118871     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mycopathologia 2014 ; 178 (ä): 341-8 Nephropedia Template TP {{tp|p=25118871|t=2014. Calcineurin-Mediated Regulation of Hyphal Growth, Septation and Virulence in Aspergillus fumigatus |pdf=|usr=}}{{25118871}} gab.com Text Calcineurin-Mediated Regulation of Hyphal Growth, Septation and Virulence in Aspergillus fumigatus JO: Mycopathologia http://www.kidney.de/pget.php?&tw=1&pmid=25118871 #FOAvip Calcineurin is a heterodimeric protein phosphatase complex composed of catalytic (CnaA) and regulatory (CnaB) subunits and plays diverse roles in regulating fungal stress responses, morphogenesis, and pathogenesis. Fungal pathogens utilize the calcineurin pathway to survive in the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making calcineurin a promising antifungal drug target. Here we review novel findings on calcineurin localization and functions in A. fumigatus hyphal growth and septum formation through regulation of proteins involved in cell wall biosynthesis. Extensive mutational analysis in the functional domains of A. fumigatus CnaA has led to an understanding of the relevance of these domains for the localization and function of CnaA at the hyphal septum. An evolutionarily conserved novel mode of calcineurin regulation by phosphorylation in filamentous fungi was found to be responsible for virulence in A. fumigatus. This finding of a filamentous fungal-specific mechanism controlling hyphal growth and virulence represents a potential target for antifungal therapy. Twit Text FOAVip Calcineurin-Mediated Regulation of Hyphal Growth, Septation and Virulence in Aspergillus fumigatus ????Mycopathologia http://www.kidney.de/pget.php?&tw=1&pmid=25118871 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25118871 #FOAvip English Wikipedia <ref>{{Cite pmid|25118871}}</ref> Calcineurin-Mediated Regulation of Hyphal Growth, Septation and Virulence in Aspergillus fumigatus #MMPMID25118871 Juvvadi PR; Lamoth F; Steinbach WJ Mycopathologia 2014[Dec]; 178 (ä): 341-8 PMID25118871show ga Calcineurin is a heterodimeric protein phosphatase complex composed of catalytic (CnaA) and regulatory (CnaB) subunits and plays diverse roles in regulating fungal stress responses, morphogenesis, and pathogenesis. Fungal pathogens utilize the calcineurin pathway to survive in the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making calcineurin a promising antifungal drug target. Here we review novel findings on calcineurin localization and functions in A. fumigatus hyphal growth and septum formation through regulation of proteins involved in cell wall biosynthesis. Extensive mutational analysis in the functional domains of A. fumigatus CnaA has led to an understanding of the relevance of these domains for the localization and function of CnaA at the hyphal septum. An evolutionarily conserved novel mode of calcineurin regulation by phosphorylation in filamentous fungi was found to be responsible for virulence in A. fumigatus. This finding of a filamentous fungal-specific mechanism controlling hyphal growth and virulence represents a potential target for antifungal therapy. äCalcineurin-Mediated Regulation of Hyphal Growth, Septation and Virule(epmc).pdf DeepDyve Pubget Overpricing