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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Psychophysiology 2014 ; 51 (12): 1272-84 Nephropedia Template TP
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Heritability and molecular genetic basis of antisaccade eye tracking error rate: A genome-wide association study #MMPMID25387707
Vaidyanathan U; Malone SM; Donnelly JM; Hammer MA; Miller MB; McGue M; Iacono WG
Psychophysiology 2014[Dec]; 51 (12): 1272-84 PMID25387707show ga
Antisaccade deficits reflect abnormalities in executive function linked to various disorders including schizophrenia, externalizing psychopathology, and neurological conditions. We examined the genetic bases of antisaccade error in a sample of community-based twins and parents (N = 4,469). Biometric models showed that about half of the variance in the antisaccade response was due to genetic factors and half due to nonshared environmental factors. Molecular genetic analyses supported these results, showing that the heritability accounted for by common molecular genetic variants approximated biometric estimates. Genome-wide analyses revealed several SNPs as well as two genes?B3GNT7 and NCL?on Chromosome 2 associated with antisaccade error. SNPs and genes hypothesized to be associated with antisaccade error based on prior work, although generating some suggestive findings for MIR137, GRM8, and CACNG2, could not be confirmed.