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2014 ; 25
(12
): 1639-43
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Symptom persistence in a community cohort of women with interstitial
cystitis/bladder pain syndrome (IC/BPS): 3-, 6-, 9-, and 12-month follow-up from
the RICE cohort
#MMPMID24915839
Suskind AM
; Berry SH
; Suttorp MJ
; Elliott MN
; Clemens JQ
Int Urogynecol J
2014[Dec]; 25
(12
): 1639-43
PMID24915839
show ga
INTRODUCTION AND HYPOTHESIS: The persistence of interstitial cystitis/bladder
pain syndrome (IC/BPS) symptoms has been described in women seeking medical care.
The purpose of this study was to determine whether symptoms persist among a
population-based sample of women. METHODS: A probability sample of US women was
identified through a two-stage telephone screening process using the Research and
Development (RAND) Interstitial Cystitis Epidemiology (RICE) high-sensitivity
case definition. A randomly selected subgroup (n?=?508) was enrolled in a
longitudinal study and interviewed about their symptoms at baseline, 3, 6, 9, and
12 months. Bivariate and multivariate linear regression analyses determined
predictors of persistence of symptoms over the four waves. RESULTS: A total of
436 women with a mean age of 47.5 years responding to all waves were included in
the analysis. Forty-one percent met the RICE high-sensitivity case definition at
baseline and in all four waves; an additional 21 % met the definition at baseline
and in three waves. Women with a college degree (+12 % vs. no college, p?=?0.02)
and who were younger (-5 % per decade of age, p?0.01) had higher chances of
symptom persistence at each wave. Scoring one standard deviation higher on the
continuity of symptoms and the O'Leary-Sant Interstitial Cystitis Symptom index
increased the chances of symptom persistence by 4 % and 2 %, respectively (both
p?0.01). CONCLUSIONS: The majority of women demonstrated symptom persistence
across at least three of four waves over 12 months. These women tended to be
younger, college-educated, and to have reported a history of greater continuity
of symptoms and higher severity of symptoms at baseline.