Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s10620-014-3248-6 http://scihub22266oqcxt.onion/10.1007/s10620-014-3248-6 C4237622!4237622!24957400     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dig+Dis+Sci 2014 ; 59 (12): 2913-26 Nephropedia Template TP {{tp|p=24957400|t=2014. Cost-effectiveness and Diagnostic effectiveness Analyses of Multiple Algorithms for the Diagnosis of Lynch Syndrome |pdf=|usr=}}{{24957400}} gab.com Text Cost-effectiveness and Diagnostic effectiveness Analyses of Multiple Algorithms for the Diagnosis of Lynch Syndrome JO: Dig Dis Sci http://www.kidney.de/pget.php?&tw=1&pmid=24957400 #FOAvip Background & Aims: The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the Revised Bethesda Guidelines (RBG) cannot be applied in a considerable number of cases due to missing information. Methods: We developed a model to evaluate the cost-effectiveness of 10 strategies for diagnosing LS. Three main issues are addressed: modeling estimates (20?40%) of RBG applicability; comparing sequential or parallel use of MSI and IHC; and a threshold analysis of the charge value below which universal germline testing becomes the most cost effective strategy. Results: LS detection rates in RBG-based strategies decreased to 64.1%-70.6% with 20% inapplicable RBG. The strategy that uses MSI alone had lower yield but also lower cost than strategies that use MSI sequentially or in parallel with IHC. The use of MSI and IHC in parallel was less affected by variations in the sensitivity and specificity of these tests. Universal germline testing had the highest yield and the highest cost of all strategies. The model estimated that if charges for germline testing drop to $633?1518, universal testing of all newly diagnosed CRC cases becomes the most cost effective strategy. Conclusions: The low applicability of RBG makes strategies employing initial laboratory based testing more cost effective. Of these strategies, parallel testing with MSI and IHC offers the most robust yield. With a considerable drop in cost, universal germline testing may become the most cost effective strategy for the diagnosis of LS. Twit Text FOAVip Cost-effectiveness and Diagnostic effectiveness Analyses of Multiple Algorithms for the Diagnosis of Lynch Syndrome ????Dig Dis Sci http://www.kidney.de/pget.php?&tw=1&pmid=24957400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24957400 #FOAvip English Wikipedia <ref>{{Cite pmid|24957400}}</ref> Cost-effectiveness and Diagnostic effectiveness Analyses of Multiple Algorithms for the Diagnosis of Lynch Syndrome #MMPMID24957400 Gould M; El-Serag HB; Musher B; Franco LM; Chen GJ Dig Dis Sci 2014[Dec]; 59 (12): 2913-26 PMID24957400show ga Background & Aims: The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the Revised Bethesda Guidelines (RBG) cannot be applied in a considerable number of cases due to missing information. Methods: We developed a model to evaluate the cost-effectiveness of 10 strategies for diagnosing LS. Three main issues are addressed: modeling estimates (20?40%) of RBG applicability; comparing sequential or parallel use of MSI and IHC; and a threshold analysis of the charge value below which universal germline testing becomes the most cost effective strategy. Results: LS detection rates in RBG-based strategies decreased to 64.1%-70.6% with 20% inapplicable RBG. The strategy that uses MSI alone had lower yield but also lower cost than strategies that use MSI sequentially or in parallel with IHC. The use of MSI and IHC in parallel was less affected by variations in the sensitivity and specificity of these tests. Universal germline testing had the highest yield and the highest cost of all strategies. The model estimated that if charges for germline testing drop to $633?1518, universal testing of all newly diagnosed CRC cases becomes the most cost effective strategy. Conclusions: The low applicability of RBG makes strategies employing initial laboratory based testing more cost effective. Of these strategies, parallel testing with MSI and IHC offers the most robust yield. With a considerable drop in cost, universal germline testing may become the most cost effective strategy for the diagnosis of LS. äCost-effectiveness and Diagnostic effectiveness Analyses of Multiple A(epmc).pdf DeepDyve Pubget Overpricing