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Review of diagnostic instruments for the restless legs syndrome/Willis-Ekbom
Disease (RLS/WED): critique and recommendations
#MMPMID25348242
Walters AS
; Frauscher B
; Allen R
; Benes H
; Chaudhuri KR
; Garcia-Borreguero D
; Lee HB
; Picchietti DL
; Trenkwalder C
; Martinez-Martin P
; Stebbins GT
; Schrag A
J Clin Sleep Med
2014[Dec]; 10
(12
): 1343-9
PMID25348242
show ga
OBJECTIVES: Over the last decade, increased research on therapy, pathogenesis,
epidemiological and genetic aspects of restless legs syndrome/Willis-Ekbom
Disease (RLS/WED) has necessitated development of diagnostic instruments specific
to RLS. The Movement Disorder Society commissioned a task force to formally
evaluate the available evidence on diagnostic instruments in RLS. METHODS: A
literature search identified 4 instruments specific to RLS. Each instrument was
evaluated by 3 criteria, which included (a) use in RLS, (b) use by groups other
than the group that developed the instrument, and (c) formal validation and
adequate clinimetric properties. Instruments were then qualified as "Recommended"
when all 3 criteria were met, "Suggested" when used for RLS but only one of the
other criteria are met, and "Listed" when used in RLS but there is absence of the
other 2 criteria. Details regarding the development, use, and clinimetric
properties of each instrument are summarized, along with the recommendations of
the committee. RESULTS AND CONCLUSION: The Recommended diagnostic instruments are
the Hening Telephone Diagnostic Interview (HTDI), the Cambridge-Hopkins
diagnostic questionnaire for RLS (CH-RLSq), and the RLS Diagnostic Index
(RLS-DI). An unmet need is the development of a diagnostic instrument for
pediatric RLS. Diagnostic instruments are particularly useful in studies where
patients are not personally interviewed or examined in the office setting.
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