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10.1111/ajt.12934 http://scihub22266oqcxt.onion/10.1111/ajt.12934 C4236286!4236286!25359003     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2014 ; 14 (12): 2691-703 Nephropedia Template TP {{tp|p=25359003|t=2014. Superiority of Rapamycin over Tacrolimus in Preserving Non-human Primate Treg Half-life and Phenotype After Adoptive Transfer |pdf=|usr=}}{{25359003}} gab.com Text Superiority of Rapamycin over Tacrolimus in Preserving Non-human Primate Treg Half-life and Phenotype After Adoptive Transfer JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their pharmacokinetic characteristics, their optimal dose, their phenotypic stability, and the best therapies with which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large (75±11 ×106 Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of elimination: an ? phase, with a T1/2 in the peripheral blood of 32.4 +/? 11.3 hours and a ? phase with a T1/2 of 120.4 +/? 19.7 hours. In addition to their short initial half-life, Tregs underwent rapid phenotypic shifts after infusion, with significant loss of both CD25 and FoxP3 by Day +6. While tacrolimus stabilized CD25 expression, it did not improve T1/2, nor mitigate the loss of FoxP3. In contrast, rapamycin significantly stabilized both CD25 and FoxP3, and supported an increased half-life, with an ? phase of 67.7+/? 6.9 hours and a ? phase of 252.1 +/? 54.9 hours. These results suggest that rapamycin may be a necessary addition to Treg immunotherapy, and that tacrolimus may be deleterious to Treg integrity post-transfer. Twit Text FOAVip Superiority of Rapamycin over Tacrolimus in Preserving Non-human Primate Treg Half-life and Phenotype After Adoptive Transfer ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip English Wikipedia <ref>{{Cite pmid|25359003}}</ref> Superiority of Rapamycin over Tacrolimus in Preserving Non-human Primate Treg Half-life and Phenotype After Adoptive Transfer #MMPMID25359003 Singh K; Stempora L; R. Donald H; Kirk A; Larsen C; Blazar B; Kean L Am J Transplant 2014[Dec]; 14 (12): 2691-703 PMID25359003show ga Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their pharmacokinetic characteristics, their optimal dose, their phenotypic stability, and the best therapies with which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large (75±11 ×106 Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of elimination: an ? phase, with a T1/2 in the peripheral blood of 32.4 +/? 11.3 hours and a ? phase with a T1/2 of 120.4 +/? 19.7 hours. In addition to their short initial half-life, Tregs underwent rapid phenotypic shifts after infusion, with significant loss of both CD25 and FoxP3 by Day +6. While tacrolimus stabilized CD25 expression, it did not improve T1/2, nor mitigate the loss of FoxP3. In contrast, rapamycin significantly stabilized both CD25 and FoxP3, and supported an increased half-life, with an ? phase of 67.7+/? 6.9 hours and a ? phase of 252.1 +/? 54.9 hours. These results suggest that rapamycin may be a necessary addition to Treg immunotherapy, and that tacrolimus may be deleterious to Treg integrity post-transfer. äSuperiority of Rapamycin over Tacrolimus in Preserving Non-human Prima(epmc).pdf DeepDyve Pubget Overpricing