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10.1111/ajt.12934 http://scihub22266oqcxt.onion/10.1111/ajt.12934 C4236286!4236286 !25359003     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25359003 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Transplant 2014 ; 14 (12 ): 2691-703 Nephropedia Template TP {{tp|p=25359003 |t=2014. Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer |pdf=|usr=}}{{25359003 }} gab.com Text Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their pharmacokinetic characteristics, their optimal dose, their phenotypic stability and the best therapies with which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large (75?±?11?×?10(6)?Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of elimination: an ? phase, with a T1/2 in the peripheral blood of 32.4?±?11.3?h and a ? phase with a T1/2 of 120.4?±?19.7?h. In addition to their short initial half-life, Tregs underwent rapid phenotypic shifts after infusion, with significant loss of both CD25 and FoxP3 by day +6. While tacrolimus stabilized CD25 expression, it did not improve T1/2 , nor mitigate the loss of FoxP3. In contrast, rapamycin significantly stabilized both CD25 and FoxP3, and supported an increased half-life, with an ? phase of 67.7?±?6.9?h and a ? phase of 252.1?±?54.9?h. These results suggest that rapamycin may be a necessary addition to Treg immunotherapy, and that tacrolimus may be deleterious to Treg integrity posttransfer. Twit Text FOAVip Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25359003 #FOAvip English Wikipedia <ref>{{Cite pmid|25359003 }}</ref> Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer #MMPMID25359003 Singh K ; Stempora L ; Harvey RD ; Kirk AD ; Larsen CP ; Blazar BR ; Kean LS Am J Transplant 2014[Dec]; 14 (12 ): 2691-703 PMID25359003 show ga Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their pharmacokinetic characteristics, their optimal dose, their phenotypic stability and the best therapies with which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large (75?±?11?×?10(6)?Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of elimination: an ? phase, with a T1/2 in the peripheral blood of 32.4?±?11.3?h and a ? phase with a T1/2 of 120.4?±?19.7?h. In addition to their short initial half-life, Tregs underwent rapid phenotypic shifts after infusion, with significant loss of both CD25 and FoxP3 by day +6. While tacrolimus stabilized CD25 expression, it did not improve T1/2 , nor mitigate the loss of FoxP3. In contrast, rapamycin significantly stabilized both CD25 and FoxP3, and supported an increased half-life, with an ? phase of 67.7?±?6.9?h and a ? phase of 252.1?±?54.9?h. These results suggest that rapamycin may be a necessary addition to Treg immunotherapy, and that tacrolimus may be deleterious to Treg integrity posttransfer. |*Adoptive Transfer [MESH] |Animals [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Flow Cytometry [MESH] |Fluoresceins [MESH] |Fluorescent Dyes [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Half-Life [MESH] |Immunosuppressive Agents/pharmacokinetics/*pharmacology [MESH] |Interleukin-2 Receptor alpha Subunit/metabolism [MESH] |Macaca mulatta [MESH] |Phenotype [MESH] |Sirolimus/pharmacokinetics/*pharmacology [MESH] |Succinimides [MESH] |T-Lymphocytes, Regulatory/drug effects/*immunology/transplantation [MESH] |Tacrolimus/pharmacokinetics/*pharmacology [MESH] |Tissue Distribution [MESH]Superiority of rapamycin over tacrolimus in preserving nonhuman primat(epmc).pdf DeepDyve Pubget Overpricing