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10.1007/s12609-014-0152-1

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C4235783!4235783!25419441
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suck abstract from ncbi


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pmid25419441      Curr+Breast+Cancer+Rep 2014 ; 6 (3): 154-8
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  • Molecular Heterogeneity of Triple Negative Breast Cancer #MMPMID25419441
  • Abramson VG; Mayer IA
  • Curr Breast Cancer Rep 2014[Sep]; 6 (3): 154-8 PMID25419441show ga
  • Triple-negative breast cancers (TNBCs) are known to be an aggressive group of breast cancers with higher rates of relapse stage for stage compared to ER/PR positive and HER2 positive breast cancers despite optimal loco-regional and systemic therapies. To date, not a single targeted therapy has been approved for the treatment of TNBC, and cytotoxic chemotherapy remains the standard systemic treatment. Recently, gene expression analyses identified six distinct TNBC subtypes, each displaying a unique biology. In this review we will discuss current and upcoming therapeutic strategies exploring novel approaches to targeted treatment of these TNBC subtypes.
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