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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Transplant+Rep 2014 ; 1 (3): 147-54 Nephropedia Template TP
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Ischemia/reperfusion Injury and its Consequences on Immunity and Inflammation #MMPMID25419507
Slegtenhorst BR; Dor FJ; Rodriguez H; Voskuil FJ; Tullius SG
Curr Transplant Rep 2014[Sep]; 1 (3): 147-54 PMID25419507show ga
Ischemia/reperfusion injury (IRI), an inherent component of transplantation, affects organ quality and transplant outcomes. Although the complexity of the pathophysiology is recognized, detailed mechanisms remain unclear, and strategies preventing the consequences of IRI have been challenging. Of critical significance appears the link between IRI, the initiation of innate immune responses, and the (potential) augmentation of adaptive immunity. An improved understanding of those complex mechanisms and interactions may pave the way for more effective treatment strategies.