Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00018-014-1701-5 http://scihub22266oqcxt.onion/10.1007/s00018-014-1701-5 C4234686!4234686!25117267     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2014 ; 71 (24): 4763-80 Nephropedia Template TP {{tp|p=25117267|t=2014. Evolution of nonclassical MHC-dependent invariant T cells |pdf=|usr=}}{{25117267}} gab.com Text Evolution of nonclassical MHC-dependent invariant T cells JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25117267 #FOAvip TCR-mediated specific recognition of antigenic peptides in the context of classical MHC molecules is a cornerstone of adaptive immunity of jawed vertebrate. Ancillary to these interactions, the T cell repertoire also includes unconventional T cells that recognize endogenous and/or exogenous antigens in a classical MHC-unrestricted manner. Among these, the mammalian nonclassical MHC class I-restricted invariant T cell (iT) subsets, such as iNKT and MAIT cells, are now believed to be integral to immune response initiation as well as in orchestrating subsequent adaptive immunity. Until recently the evolutionary origins of these cells were unknown. Here we review our current understanding of a nonclassical MHC class I-restricted iT cell population in the amphibian Xenopus laevis. Parallels with the mammalian iNKT and MAIT cells underline the crucial biological roles of these evolutionarily ancient immune subsets. Twit Text FOAVip Evolution of nonclassical MHC-dependent invariant T cells ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25117267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25117267 #FOAvip English Wikipedia <ref>{{Cite pmid|25117267}}</ref> Evolution of nonclassical MHC-dependent invariant T cells #MMPMID25117267 Edholm ES; Grayfer L; Robert J Cell Mol Life Sci 2014[Dec]; 71 (24): 4763-80 PMID25117267show ga TCR-mediated specific recognition of antigenic peptides in the context of classical MHC molecules is a cornerstone of adaptive immunity of jawed vertebrate. Ancillary to these interactions, the T cell repertoire also includes unconventional T cells that recognize endogenous and/or exogenous antigens in a classical MHC-unrestricted manner. Among these, the mammalian nonclassical MHC class I-restricted invariant T cell (iT) subsets, such as iNKT and MAIT cells, are now believed to be integral to immune response initiation as well as in orchestrating subsequent adaptive immunity. Until recently the evolutionary origins of these cells were unknown. Here we review our current understanding of a nonclassical MHC class I-restricted iT cell population in the amphibian Xenopus laevis. Parallels with the mammalian iNKT and MAIT cells underline the crucial biological roles of these evolutionarily ancient immune subsets. äEvolution of nonclassical MHC-dependent invariant T cells (epmc).pdf DeepDyve Pubget Overpricing