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10.1152/jn.00140.2014

http://scihub22266oqcxt.onion/10.1152/jn.00140.2014
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suck abstract from ncbi


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pmid25143546
      J+Neurophysiol 2014 ; 112 (10 ): 2529-44
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  • Reversible deactivation of higher-order posterior parietal areas I Alterations of receptive field characteristics in early stages of neocortical processing #MMPMID25143546
  • Cooke DF ; Goldring AB ; Baldwin MK ; Recanzone GH ; Chen A ; Pan T ; Simon SI ; Krubitzer L
  • J Neurophysiol 2014[Nov]; 112 (10 ): 2529-44 PMID25143546 show ga
  • Somatosensory processing in the anesthetized macaque monkey was examined by reversibly deactivating posterior parietal areas 5L and 7b and motor/premotor cortex (M1/PM) with microfluidic thermal regulators developed by our laboratories. We examined changes in receptive field size and configuration for neurons in areas 1 and 2 that occurred during and after cooling deactivation. Together the deactivated fields and areas 1 and 2 form part of a network for reaching and grasping in human and nonhuman primates. Cooling area 7b had a dramatic effect on receptive field size for neurons in areas 1 and 2, while cooling area 5 had moderate effects and cooling M1/PM had little effect. Specifically, cooling discrete locations in 7b resulted in expansions of the receptive fields for neurons in areas 1 and 2 that were greater in magnitude and occurred in a higher proportion of sites than similar changes evoked by cooling the other fields. At some sites, the neural receptive field returned to the precooling configuration within 5-22 min of rewarming, but at other sites changes in receptive fields persisted. These results indicate that there are profound top-down influences on sensory processing of early cortical areas in the somatosensory cortex.
  • |Animals [MESH]
  • |Cold Temperature [MESH]
  • |Female [MESH]
  • |Hand/*physiology [MESH]
  • |Macaca mulatta [MESH]
  • |Male [MESH]
  • |Microelectrodes [MESH]
  • |Motor Activity/physiology [MESH]
  • |Motor Cortex/physiology [MESH]
  • |Neurons/*physiology [MESH]
  • |Parietal Lobe/*physiology [MESH]
  • |Physical Stimulation [MESH]


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