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2014 ; 36
(6
): 9729
Nephropedia Template TP
gab.com Text
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Ageing and myeloid-derived suppressor cells: possible involvement in
immunosenescence and age-related disease
#MMPMID25399072
Bueno V
; Sant'Anna OA
; Lord JM
Age (Dordr)
2014[]; 36
(6
): 9729
PMID25399072
show ga
Infections, cancer and autoimmune diseases occur more frequently in the elderly,
and although many factors contribute to this, the age-related remodelling of the
immune system, termed immunosenescence, plays a major role. Over the last two
decades, studies have evaluated the effect of ageing on both the adaptive and
innate arms of the immune system and demonstrated compromised function in several
cells including lymphocytes (naïve, effector and memory), regulatory T and B
cells, monocytes, neutrophils and NK cells. In addition, a well-documented
feature of ageing is the increase in systemic inflammatory status
(inflammageing), with raised serum levels of IL6, TNF? and CRP as well as reduced
IL10. Recently, myeloid-derived suppressor cells have been the focus of many
reports as these cells show immunosuppressive properties and are present in
higher frequency during infections, cancer and autoimmunity. Importantly, there
have been publications showing increased numbers of myeloid-derived suppressor
cells in aged mice and humans. In this review, we discuss the current literature
on myeloid-derived suppressor cells, their possible role in altered immune
function in the elderly, and whether it may be possible to manipulate these cells
to alleviate age-related immune dysfunction.