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10.1002/eji.201344424 http://scihub22266oqcxt.onion/10.1002/eji.201344424 C4232983!4232983 !25103892     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25103892 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2014 ; 44 (11 ): 3429-38 Nephropedia Template TP {{tp|p=25103892 |t=2014. DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells |pdf=|usr=}}{{25103892 }} gab.com Text DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25103892 #FOAvip HLA-DRB1*0401 expression in humans has been associated with a predisposition to developing rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), while HLA-DRB1*0402 is not associated with susceptibility. Here, we determined if mice transgenic (Tg) for human *0401 have a CD4+ T-cell repertoire that predetermines proinflammatory cytokine production. The data show that both *0401 and *0402 Tg mice can produce TH1/TH17 cytokines, although the kinetics of response may be different. However, in the context of antigen-specific responses in a CIA model, *0402 Tg mice generate a TH2 response that may explain their resistance to developing arthritis. In addition, a significant subset of naïve CD4+ T cells from *0402 Tg mice can be activated in polarizing conditions to differentiate into Treg cells that produce IFN-?. *0401 Tg mice harbor memory CD4+ T cells that differentiate into IL-17(+) cells in various polarizing conditions. Our data suggest that *0401 Tg mice generate a strong immune response to lipopolysaccharide and may be efficient in clearing infection, and may *0401 have been evolutionarily selected for this ability. Autoimmunity, such as RA, could likely be a bystander effect of the cytokine storm that, along with the presence of low Treg-cell numbers in *0401 Tg mice, causes immune dysregulation. Twit Text FOAVip DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25103892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25103892 #FOAvip English Wikipedia <ref>{{Cite pmid|25103892 }}</ref> DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells #MMPMID25103892 Luckey D ; Behrens M ; Smart M ; Luthra H ; David CS ; Taneja V Eur J Immunol 2014[Nov]; 44 (11 ): 3429-38 PMID25103892 show ga HLA-DRB1*0401 expression in humans has been associated with a predisposition to developing rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), while HLA-DRB1*0402 is not associated with susceptibility. Here, we determined if mice transgenic (Tg) for human *0401 have a CD4+ T-cell repertoire that predetermines proinflammatory cytokine production. The data show that both *0401 and *0402 Tg mice can produce TH1/TH17 cytokines, although the kinetics of response may be different. However, in the context of antigen-specific responses in a CIA model, *0402 Tg mice generate a TH2 response that may explain their resistance to developing arthritis. In addition, a significant subset of naïve CD4+ T cells from *0402 Tg mice can be activated in polarizing conditions to differentiate into Treg cells that produce IFN-?. *0401 Tg mice harbor memory CD4+ T cells that differentiate into IL-17(+) cells in various polarizing conditions. Our data suggest that *0401 Tg mice generate a strong immune response to lipopolysaccharide and may be efficient in clearing infection, and may *0401 have been evolutionarily selected for this ability. Autoimmunity, such as RA, could likely be a bystander effect of the cytokine storm that, along with the presence of low Treg-cell numbers in *0401 Tg mice, causes immune dysregulation. |Animals [MESH] |Arthritis, Experimental/*immunology [MESH] |Arthritis, Rheumatoid/immunology [MESH] |Cell Differentiation/immunology [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Female [MESH] |HLA-DRB1 Chains/genetics/*immunology [MESH] |Inflammation/immunology [MESH] |Interleukin-17/biosynthesis [MESH] |Lipopolysaccharides/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |T-Lymphocytes, Regulatory/*cytology/immunology [MESH] |Th1 Cells/immunology [MESH] |Th17 Cells/immunology [MESH]DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell diffe(epmc).pdf DeepDyve Pubget Overpricing