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10.1074/jbc.M114.565838

http://scihub22266oqcxt.onion/10.1074/jbc.M114.565838
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C4231659!4231659!25258312
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suck abstract from ncbi


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pmid25258312      J+Biol+Chem 2014 ; 289 (46): 31818-26
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  • DEPTOR Is a Stemness Factor That Regulates Pluripotency of Embryonic Stem Cells* #MMPMID25258312
  • Agrawal P; Reynolds J; Chew S; Lamba DA; Hughes RE
  • J Biol Chem 2014[Nov]; 289 (46): 31818-26 PMID25258312show ga
  • Background: DEPTOR is a negative regulator of mTOR activity and thus plays a role in the regulation of cell metabolism and growth.Results: DEPTOR levels decrease upon differentiation of embryonic stem cells, and reduction of DEPTOR levels is sufficient to promote differentiation.Conclusion: DEPTOR is a stemness factor that regulates pluripotency.Significance: Manipulation of DEPTOR activity provides a means of influencing embryonic stem cell renewal and differentiation.
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