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10.1111/psyp.12346

http://scihub22266oqcxt.onion/10.1111/psyp.12346
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suck abstract from ncbi


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pmid25387706
      Psychophysiology 2014 ; 51 (12 ): 1259-71
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  • Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study #MMPMID25387706
  • Vaidyanathan U ; Isen JD ; Malone SM ; Miller MB ; McGue M ; Iacono WG
  • Psychophysiology 2014[Dec]; 51 (12 ): 1259-71 PMID25387706 show ga
  • The molecular genetic basis of electrodermal activity (EDA) was analyzed using 527,829 single nucleotide polymorphisms (SNPs) in a large population-representative sample of twins and parents (N?=?4,424) in relation to various EDA indices. Biometric analyses suggested that approximately 50% or more of variance in all EDA indices was heritable. The combined effect of all SNPs together accounted for a significant amount of variance in each index, affirming their polygenic basis and heritability. However, none of the SNPs were genome-wide significant for any EDA index. Previously reported SNP associations with disorders such as substance dependence or schizophrenia, which have been linked to EDA abnormalities, were not significant; nor were associations between EDA and genes in specific neurotransmitter systems. These results suggest that EDA is influenced by multiple genes rather than by polymorphisms with large effects.
  • |*Endophenotypes [MESH]
  • |*Polymorphism, Single Nucleotide [MESH]
  • |Adolescent [MESH]
  • |Female [MESH]
  • |Galvanic Skin Response/*genetics [MESH]
  • |Genome-Wide Association Study [MESH]
  • |Genotype [MESH]
  • |Humans [MESH]
  • |Male [MESH]


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