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2014 ; 51
(12
): 1259-71
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Heritability and molecular genetic basis of electrodermal activity: a genome-wide
association study
#MMPMID25387706
Vaidyanathan U
; Isen JD
; Malone SM
; Miller MB
; McGue M
; Iacono WG
Psychophysiology
2014[Dec]; 51
(12
): 1259-71
PMID25387706
show ga
The molecular genetic basis of electrodermal activity (EDA) was analyzed using
527,829 single nucleotide polymorphisms (SNPs) in a large
population-representative sample of twins and parents (N?=?4,424) in relation to
various EDA indices. Biometric analyses suggested that approximately 50% or more
of variance in all EDA indices was heritable. The combined effect of all SNPs
together accounted for a significant amount of variance in each index, affirming
their polygenic basis and heritability. However, none of the SNPs were
genome-wide significant for any EDA index. Previously reported SNP associations
with disorders such as substance dependence or schizophrenia, which have been
linked to EDA abnormalities, were not significant; nor were associations between
EDA and genes in specific neurotransmitter systems. These results suggest that
EDA is influenced by multiple genes rather than by polymorphisms with large
effects.