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2014 ; 51
(12
): 1201-2
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English Wikipedia
Genome-wide scans of genetic variants for psychophysiological endophenotypes:
introduction to this special issue of Psychophysiology
#MMPMID25387700
Iacono WG
Psychophysiology
2014[Dec]; 51
(12
): 1201-2
PMID25387700
show ga
This special issue addresses the heritability and molecular genetic basis of 17
putative endophenotypes involving resting EEG power, P300 event-related potential
amplitude, electrodermal orienting and habituation, antisaccade eye tracking, and
affective modulation of the startle eye blink. These measures were collected from
approximately 4,900 twins and parents who provided DNA samples through their
participation in the Minnesota Twin Family Study. Included are papers that detail
the methodology followed, genome-wide association analyses of single nucleotide
polymorphisms and genes, analysis of rare variants in the human exome, and a
whole genome sequencing study. Also included are 11 articles by leading experts
in psychophysiology and genetics that provide perspective and commentary. A final
integrative report summarizes findings and addresses issues raised. This
introduction provides an overview of the aims and rationale behind these studies.