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10.1038/bjc.2014.486 http://scihub22266oqcxt.onion/10.1038/bjc.2014.486 C4229631!4229631 !25314062     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25314062 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Cancer 2014 ; 111 (10 ): 1945-54 Nephropedia Template TP {{tp|p=25314062 |t=2014. Direct incorporation of the NKT-cell activator ?-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy |pdf=|usr=}}{{25314062 }} gab.com Text Direct incorporation of the NKT-cell activator -galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25314062 #FOAvip BACKGROUND: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid ?-galactosylceramide could overcome immune suppression and improve vaccination against metastatic breast cancer. METHODS: Mice with metastatic breast cancer (4T1 model) were therapeutically treated with a Listeria monocytogenes-based vaccine expressing tumour-associated antigen Mage-b followed by ?-galactosylceramide as separate agents, or as a complex of ?-galactosylceramide stably incorporated into Listeria-Mage-b. Effects on metastases, tumour weight, toxicity and immune responses were determined. RESULTS: Sequential treatments of mice with established 4T1 breast carcinomas using Listeria-Mage-b followed by ?-galactosylceramide as a separate agent was highly effective at reducing metastases, but was accompanied by severe liver toxicity. In contrast, combined therapy using Listeria-Mage-b modified by incorporation of ?-galactosylceramide resulted in nearly complete elimination of metastases without toxicity. This was associated with a significant increase in the percentage of natural killer T cells in the spleen, and an increase in natural killer cell activity and in T cell responses to Mage-b. CONCLUSIONS: Our results suggest that direct incorporation of ?-galactosylceramide into a live bacterial vaccine vector is a promising non-toxic new approach for the treatment of metastatic breast cancer. Twit Text FOAVip Direct incorporation of the NKT-cell activator -galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25314062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25314062 #FOAvip English Wikipedia <ref>{{Cite pmid|25314062 }}</ref> Direct incorporation of the NKT-cell activator ?-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy #MMPMID25314062 Singh M ; Quispe-Tintaya W ; Chandra D ; Jahangir A ; Venkataswamy MM ; Ng TW ; Sharma-Kharkwal S ; Carreņo LJ ; Porcelli SA ; Gravekamp C Br J Cancer 2014[Nov]; 111 (10 ): 1945-54 PMID25314062 show ga BACKGROUND: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid ?-galactosylceramide could overcome immune suppression and improve vaccination against metastatic breast cancer. METHODS: Mice with metastatic breast cancer (4T1 model) were therapeutically treated with a Listeria monocytogenes-based vaccine expressing tumour-associated antigen Mage-b followed by ?-galactosylceramide as separate agents, or as a complex of ?-galactosylceramide stably incorporated into Listeria-Mage-b. Effects on metastases, tumour weight, toxicity and immune responses were determined. RESULTS: Sequential treatments of mice with established 4T1 breast carcinomas using Listeria-Mage-b followed by ?-galactosylceramide as a separate agent was highly effective at reducing metastases, but was accompanied by severe liver toxicity. In contrast, combined therapy using Listeria-Mage-b modified by incorporation of ?-galactosylceramide resulted in nearly complete elimination of metastases without toxicity. This was associated with a significant increase in the percentage of natural killer T cells in the spleen, and an increase in natural killer cell activity and in T cell responses to Mage-b. CONCLUSIONS: Our results suggest that direct incorporation of ?-galactosylceramide into a live bacterial vaccine vector is a promising non-toxic new approach for the treatment of metastatic breast cancer. |*Immunotherapy [MESH] |Animals [MESH] |Antigens, Neoplasm/immunology [MESH] |Apoptosis [MESH] |Blotting, Western [MESH] |Cancer Vaccines/*therapeutic use [MESH] |Cell Adhesion [MESH] |Cell Cycle [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Female [MESH] |Flow Cytometry [MESH] |Galactosylceramides/*metabolism [MESH] |Immunoenzyme Techniques [MESH] |Killer Cells, Natural/*immunology/metabolism/pathology [MESH] |Listeria monocytogenes/*genetics [MESH] |Lymphocyte Activation [MESH] |Mammary Neoplasms, Experimental/genetics/immunology/pathology/*prevention & control [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/*genetics [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Recombination, Genetic [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |T-Lymphocytes/*immunology/metabolism/pathology [MESH] |Tumor Cells, Cultured [MESH]Direct incorporation of the NKT-cell activator ?-galactosylceramide in(epmc).pdf DeepDyve Pubget Overpricing