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10.1016/j.cois.2014.07.005

http://scihub22266oqcxt.onion/10.1016/j.cois.2014.07.005
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C4228475!4228475!25401084
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suck abstract from ncbi

pmid25401084      Curr+Opin+Insect+Sci 2014 ; 3 (ä): 22-9
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  • Mosquito immune responses to arbovirus infections #MMPMID25401084
  • Blair CD; Olson KE
  • Curr Opin Insect Sci 2014[Sep]; 3 (ä): 22-9 PMID25401084show ga
  • The principal mosquito innate immune response to virus infections, RNA interference (RNAi), differs substantially from the immune response to bacterial and fungal infections. The exo-siRNA pathway constitutes the major anti-arboviral RNAi response and its essential genetic components have been identified. Recent research has also implicated the Piwi-interacting RNA pathway in mosquito anti-arboviral immunity, but Piwi gene-family components involved are not well-defined. Arboviruses must evade or suppress RNAi without causing pathogenesis in the vector to maintain their transmission cycle, but little is known about mechanisms of arbovirus modulation of RNAi. Genetic manipulation of mosquitoes to enhance their RNAi response can limit arbovirus infection and replication and could be used in novel strategies for interruption of arbovirus transmission and greatly reduce disease.
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