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10.1002/adhm.201400137 http://scihub22266oqcxt.onion/10.1002/adhm.201400137 C4227912!4227912 !24923735     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24923735 &cmd=llinks): Failed to open stream: HTTP request failed! 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Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs |pdf=|usr=}}{{24923735 }} gab.com Text Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs JO: Adv Healthc Mater http://www.kidney.de/pget.php?&tw=1&pmid=24923735 #FOAvip Epitope content plays a critical role in determining T-cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly is used to build a vaccine with precise control over epitope content, in order to finely tune the magnitude and phenotype of T helper and antibody responses. Self-adjuvanting peptide nanofibers are formed by co-assembling a high-affinity universal CD4+ T-cell epitope (PADRE) and a B-cell epitope from Staphylococcus aureus at specifiable concentrations. Increasing the PADRE concentration from micromolar to millimolar elicited bell-shaped dose-responses that are unique to different T-cell populations. Notably, the epitope ratios that maximize T follicular helper and antibody responses differed by an order of magnitude from those that maximized Th1 or Th2 responses. Thus, modular materials assembly provides a means of controlling epitope content and efficiently skewing the adaptive immune response in the absence of exogenous adjuvant; this approach may contribute to the development of improved vaccines and immunotherapies. Twit Text FOAVip Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs ????Adv Healthc Mater http://www.kidney.de/pget.php?&tw=1&pmid=24923735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24923735 #FOAvip English Wikipedia <ref>{{Cite pmid|24923735 }}</ref> Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs #MMPMID24923735 Pompano RR ; Chen J ; Verbus EA ; Han H ; Fridman A ; McNeely T ; Collier JH ; Chong AS Adv Healthc Mater 2014[Nov]; 3 (11 ): 1898-908 PMID24923735 show ga Epitope content plays a critical role in determining T-cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly is used to build a vaccine with precise control over epitope content, in order to finely tune the magnitude and phenotype of T helper and antibody responses. Self-adjuvanting peptide nanofibers are formed by co-assembling a high-affinity universal CD4+ T-cell epitope (PADRE) and a B-cell epitope from Staphylococcus aureus at specifiable concentrations. Increasing the PADRE concentration from micromolar to millimolar elicited bell-shaped dose-responses that are unique to different T-cell populations. Notably, the epitope ratios that maximize T follicular helper and antibody responses differed by an order of magnitude from those that maximized Th1 or Th2 responses. Thus, modular materials assembly provides a means of controlling epitope content and efficiently skewing the adaptive immune response in the absence of exogenous adjuvant; this approach may contribute to the development of improved vaccines and immunotherapies. |Animals [MESH] |Antibodies/*immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |Epitopes, T-Lymphocyte/*immunology [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Staphylococcus aureus/immunology [MESH] |Th1 Cells/*immunology [MESH] |Th2 Cells/*immunology [MESH]Titrating T-cell epitopes within self-assembled vaccines optimizes CD4(epmc).pdf DeepDyve Pubget Overpricing