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10.1038/cdd.2014.96 http://scihub22266oqcxt.onion/10.1038/cdd.2014.96 C4227156!4227156 !25012502     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25012502 &cmd=llinks): Failed to open stream: HTTP request failed! 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RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells |pdf=|usr=}}{{25012502 }} gab.com Text RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25012502 #FOAvip Pancreatic cancer is characterized by a microenvironment suppressing immune responses. RIG-I-like helicases (RLH) are immunoreceptors for viral RNA that induce an antiviral response program via the production of type I interferons (IFN) and apoptosis in susceptible cells. We recently identified RLH as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction. Here, we investigated immunogenic consequences of RLH-induced tumor cell death. Treatment of murine pancreatic cancer cell lines with RLH ligands induced production of type I IFN and proinflammatory cytokines. In addition, tumor cells died via intrinsic apoptosis and displayed features of immunogenic cell death, such as release of HMGB1 and translocation of calreticulin to the outer cell membrane. RLH-activated tumor cells led to activation of dendritic cells (DCs), which was mediated by tumor-derived type I IFN, whereas TLR, RAGE or inflammasome signaling was dispensable. Importantly, CD8?(+) DCs effectively engulfed apoptotic tumor material and cross-presented tumor-associated antigen to naive CD8(+) T cells. In comparison, tumor cell death mediated by oxaliplatin, staurosporine or mechanical disruption failed to induce DC activation and antigen presentation. Tumor cells treated with sublethal doses of RLH ligands upregulated Fas and MHC-I expression and were effectively sensitized towards Fas-mediated apoptosis and cytotoxic T lymphocyte (CTL)-mediated lysis. Vaccination of mice with RLH-activated tumor cells induced protective antitumor immunity in vivo. In addition, MDA5-based immunotherapy led to effective tumor control of established pancreatic tumors. In summary, RLH ligands induce a highly immunogenic form of tumor cell death linking innate and adaptive immunity. Twit Text FOAVip RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25012502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25012502 #FOAvip English Wikipedia <ref>{{Cite pmid|25012502 }}</ref> RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells #MMPMID25012502 Duewell P ; Steger A ; Lohr H ; Bourhis H ; Hoelz H ; Kirchleitner SV ; Stieg MR ; Grassmann S ; Kobold S ; Siveke JT ; Endres S ; Schnurr M Cell Death Differ 2014[Dec]; 21 (12 ): 1825-37 PMID25012502 show ga Pancreatic cancer is characterized by a microenvironment suppressing immune responses. RIG-I-like helicases (RLH) are immunoreceptors for viral RNA that induce an antiviral response program via the production of type I interferons (IFN) and apoptosis in susceptible cells. We recently identified RLH as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction. Here, we investigated immunogenic consequences of RLH-induced tumor cell death. Treatment of murine pancreatic cancer cell lines with RLH ligands induced production of type I IFN and proinflammatory cytokines. In addition, tumor cells died via intrinsic apoptosis and displayed features of immunogenic cell death, such as release of HMGB1 and translocation of calreticulin to the outer cell membrane. RLH-activated tumor cells led to activation of dendritic cells (DCs), which was mediated by tumor-derived type I IFN, whereas TLR, RAGE or inflammasome signaling was dispensable. Importantly, CD8?(+) DCs effectively engulfed apoptotic tumor material and cross-presented tumor-associated antigen to naive CD8(+) T cells. In comparison, tumor cell death mediated by oxaliplatin, staurosporine or mechanical disruption failed to induce DC activation and antigen presentation. Tumor cells treated with sublethal doses of RLH ligands upregulated Fas and MHC-I expression and were effectively sensitized towards Fas-mediated apoptosis and cytotoxic T lymphocyte (CTL)-mediated lysis. Vaccination of mice with RLH-activated tumor cells induced protective antitumor immunity in vivo. In addition, MDA5-based immunotherapy led to effective tumor control of established pancreatic tumors. In summary, RLH ligands induce a highly immunogenic form of tumor cell death linking innate and adaptive immunity. |Animals [MESH] |Apoptosis/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cell Line, Tumor [MESH] |Cross-Priming [MESH] |Cytokines/metabolism [MESH] |Cytotoxicity, Immunologic [MESH] |DEAD-box RNA Helicases/*physiology [MESH] |Dendritic Cells/immunology [MESH] |Female [MESH] |Immunotherapy [MESH] |Inflammasomes/metabolism [MESH] |Interferon Type I/physiology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neoplasm Transplantation [MESH] |Pancreatic Neoplasms/immunology/*pathology/therapy [MESH] |T-Lymphocytes, Cytotoxic/immunology [MESH]RIG-I-like helicases induce immunogenic cell death of pancreatic cance(epmc).pdf DeepDyve Pubget Overpricing