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10.1038/ni.2985 http://scihub22266oqcxt.onion/10.1038/ni.2985 C4226759!4226759!25194422     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2014 ; 15 (10): 957-64 Nephropedia Template TP {{tp|p=25194422|t=2014. Bcl-6 directly represses the gene program of the glycolysis pathway |pdf=|usr=}}{{25194422}} gab.com Text Bcl-6 directly represses the gene program of the glycolysis pathway JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25194422 #FOAvip Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in TH1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1? promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation. Twit Text FOAVip Bcl-6 directly represses the gene program of the glycolysis pathway ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25194422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25194422 #FOAvip English Wikipedia <ref>{{Cite pmid|25194422}}</ref> Bcl-6 directly represses the gene program of the glycolysis pathway #MMPMID25194422 Oestreich KJ; Read KA; Gilbertson SE; Hough KP; McDonald PW; Krishnamoorthy V; Weinmann AS Nat Immunol 2014[Oct]; 15 (10): 957-64 PMID25194422show ga Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in TH1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1? promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation. äBcl-6 directly represses the gene program of the glycolysis pathway (epmc).pdf DeepDyve Pubget Overpricing