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10.1007/s11888-014-0252-3 http://scihub22266oqcxt.onion/10.1007/s11888-014-0252-3 C4226438!4226438!25395896     free     free     free       Curr+Colorectal+Cancer+Rep 2014 ; 10 (4): 411-6 Nephropedia Template TP {{tp|p=25395896|t=2014. Targeting Notch Signaling in Colorectal Cancer |pdf=|usr=}}{{25395896}} gab.com Text Targeting Notch Signaling in Colorectal Cancer JO: Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=25395896 #FOAvip The activation of Notch signaling is implicated in tumorigenesis in the colon due to the induction of pro-survival signaling in colonic epithelial cells. Chemoresistance is a major obstacle for treatment and for the complete eradication of colorectal cancer (CRC), hence, the inhibition of Notch is an attractive target for CRC and several groups are working to identify small molecules or monoclonal antibodies that inhibit Notch or its downstream events; however, toxicity profiles in normal cells and organs often impede the clinical translation of these molecules. Dietary agents have gained momentum for targeting several pro-survival signaling cascades, and recent studies demonstrated that agents that inhibit Notch signaling result in growth inhibition in preclinical models of CRC. In this review, we focus on the importance of Notch as a preventive and therapeutic target for colon cancer and on the effect of WA on this signaling pathway in the context of colon cancer. Twit Text FOAVip Targeting Notch Signaling in Colorectal Cancer ????Curr Colorectal Cancer Rep http://www.kidney.de/pget.php?&tw=1&pmid=25395896 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25395896 #FOAvip English Wikipedia <ref>{{Cite pmid|25395896}}</ref> Targeting Notch Signaling in Colorectal Cancer #MMPMID25395896 Suman S; Das TP; Ankem MK; Damodaran C Curr Colorectal Cancer Rep 2014[Dec]; 10 (4): 411-6 PMID25395896show ga The activation of Notch signaling is implicated in tumorigenesis in the colon due to the induction of pro-survival signaling in colonic epithelial cells. Chemoresistance is a major obstacle for treatment and for the complete eradication of colorectal cancer (CRC), hence, the inhibition of Notch is an attractive target for CRC and several groups are working to identify small molecules or monoclonal antibodies that inhibit Notch or its downstream events; however, toxicity profiles in normal cells and organs often impede the clinical translation of these molecules. Dietary agents have gained momentum for targeting several pro-survival signaling cascades, and recent studies demonstrated that agents that inhibit Notch signaling result in growth inhibition in preclinical models of CRC. In this review, we focus on the importance of Notch as a preventive and therapeutic target for colon cancer and on the effect of WA on this signaling pathway in the context of colon cancer. äTargeting Notch Signaling in Colorectal Cancer (epmc).pdf DeepDyve Pubget Overpricing