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10.1164/rccm.201401-0079OC http://scihub22266oqcxt.onion/10.1164/rccm.201401-0079OC C4226053!4226053!24921217     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2014 ; 190 (2): 185-95 Nephropedia Template TP {{tp|p=24921217|t=2014. Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis |pdf=|usr=}}{{24921217}} gab.com Text Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24921217 #FOAvip Rationale: Wnt/?-catenin signaling has been implicated in lung fibrosis, but how this occurs and whether expression changes in Wnt pathway components predict disease progression is unknown.Objectives: To determine whether the Wnt coreceptor Lrp5 drives pulmonary fibrosis in mice and is predictive of disease severity in humans.Methods: We examined mice with impaired Wnt signaling caused by loss of the Wnt coreceptor Lrp5 in models of lung fibrosis induced by bleomycin or an adenovirus encoding an active form of transforming growth factor (TGF)-?. We also analyzed gene expression in peripheral blood mononuclear cells (PBMC) from patients with idiopathic pulmonary fibrosis (IPF).Measurements and Main Results: In patients with IPF, analysis of peripheral blood mononuclear cells revealed that elevation of positive regulators, Lrp5 and 6, was independently associated with disease progression. LRP5 was also associated with disease severity at presentation in an additional cohort of patients with IPF. Lrp5 null mice were protected against bleomycin-induced pulmonary fibrosis, an effect that was phenocopied by direct inhibition of ?-catenin signaling by the small molecular inhibitor of ?-catenin responsive transcription. Transplantation of Lrp5 null bone marrow cells into wild-type mice did not limit fibrosis. Instead, Lrp5 loss was associated with reduced TGF-? production by alveolar type 2 cells and leukocytes. Consistent with a role of Lrp5 in the activation of TGF-?, Lrp5 null mice were not protected against lung fibrosis induced by TGF-?.Conclusions: We show that the Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis in mice and a marker of disease progression and severity in humans with IPF. Evidence that TGF-? signaling can override a loss in Lrp5 has implications for patient selection and timing of Wnt pathway inhibitors in lung fibrosis. Twit Text FOAVip Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24921217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24921217 #FOAvip English Wikipedia <ref>{{Cite pmid|24921217}}</ref> Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis #MMPMID24921217 Lam AP; Herazo-Maya JD; Sennello JA; Flozak AS; Russell S; Mutlu GM; Budinger GRS; DasGupta R; Varga J; Kaminski N; Gottardi CJ Am J Respir Crit Care Med 2014[Jul]; 190 (2): 185-95 PMID24921217show ga Rationale: Wnt/?-catenin signaling has been implicated in lung fibrosis, but how this occurs and whether expression changes in Wnt pathway components predict disease progression is unknown.Objectives: To determine whether the Wnt coreceptor Lrp5 drives pulmonary fibrosis in mice and is predictive of disease severity in humans.Methods: We examined mice with impaired Wnt signaling caused by loss of the Wnt coreceptor Lrp5 in models of lung fibrosis induced by bleomycin or an adenovirus encoding an active form of transforming growth factor (TGF)-?. We also analyzed gene expression in peripheral blood mononuclear cells (PBMC) from patients with idiopathic pulmonary fibrosis (IPF).Measurements and Main Results: In patients with IPF, analysis of peripheral blood mononuclear cells revealed that elevation of positive regulators, Lrp5 and 6, was independently associated with disease progression. LRP5 was also associated with disease severity at presentation in an additional cohort of patients with IPF. Lrp5 null mice were protected against bleomycin-induced pulmonary fibrosis, an effect that was phenocopied by direct inhibition of ?-catenin signaling by the small molecular inhibitor of ?-catenin responsive transcription. Transplantation of Lrp5 null bone marrow cells into wild-type mice did not limit fibrosis. Instead, Lrp5 loss was associated with reduced TGF-? production by alveolar type 2 cells and leukocytes. Consistent with a role of Lrp5 in the activation of TGF-?, Lrp5 null mice were not protected against lung fibrosis induced by TGF-?.Conclusions: We show that the Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis in mice and a marker of disease progression and severity in humans with IPF. Evidence that TGF-? signaling can override a loss in Lrp5 has implications for patient selection and timing of Wnt pathway inhibitors in lung fibrosis. äWnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis (epmc).pdf DeepDyve Pubget Overpricing