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10.1164/rccm.201401-0178OC http://scihub22266oqcxt.onion/10.1164/rccm.201401-0178OC C4226017!4226017!24821412     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2014 ; 189 (12): 1494-502 Nephropedia Template TP {{tp|p=24821412|t=2014. The Nonallergic Asthma of Obesity A Matter of Distal Lung Compliance |pdf=|usr=}}{{24821412}} gab.com Text The Nonallergic Asthma of Obesity A Matter of Distal Lung Compliance JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24821412 #FOAvip Rationale: The pathogenesis of asthma in obesity is poorly understood, but may be related to breathing at low lung volumes.Objectives: To determine if lung function in obese patients with asthma and control subjects would respond differently to weight loss.Methods: Lung function was evaluated by conventional clinical tests and by impulse oscillometry in female late-onset, nonallergic patients with asthma and control subjects before, and 12 months after, bariatric surgery.Measurements and Main Results: Patients with asthma (n = 10) had significantly lower FEV1 (79.8 ± 10.6 vs. 95.5 ± 7.0%) and FVC (82.4 ± 13.2 vs. 93.7 ± 8.9%) compared with control subjects (n = 13). There were no significant differences in FRC or TLC at baseline. Twelve months after surgery, control subjects had significant increases in FEV1 (95.5 ± 7.0 to 100.7 ± 5.9), FVC (93.6 ± 8.9 to 98.6 ± 8.3%), FRC (45.4 ± 18.5 to 62.1 ± 15.3%), and TLC (84.8 ± 15.0 to 103.1 ± 15.3%), whereas patients with asthma had improvement only in FEV1 (79.8 ± 10.6 to 87.2 ± 11.5). Control subjects and patients with asthma had a significantly different change in respiratory system resistance with weight loss: control subjects exhibited a uniform decrease in respiratory system resistance at all frequencies, whereas patients with asthma exhibited a decrease in frequency dependence of resistance. Fits of a mathematical model of lung mechanics to these impedance spectra suggest that the lung periphery was more collapsed by obesity in patients with asthma compared with control subjects.Conclusions: Weight loss decompresses the lung in both obese control subjects and patients with asthma, but the more pronounced effects of weight loss on lung elastance suggest that the distal lung is inherently more collapsible in people with asthma. Twit Text FOAVip The Nonallergic Asthma of Obesity A Matter of Distal Lung Compliance ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24821412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24821412 #FOAvip English Wikipedia <ref>{{Cite pmid|24821412}}</ref> The Nonallergic Asthma of Obesity A Matter of Distal Lung Compliance #MMPMID24821412 Al-Alwan A; Bates JHT; Chapman DG; Kaminsky DA; DeSarno MJ; Irvin CG; Dixon AE Am J Respir Crit Care Med 2014[Jun]; 189 (12): 1494-502 PMID24821412show ga Rationale: The pathogenesis of asthma in obesity is poorly understood, but may be related to breathing at low lung volumes.Objectives: To determine if lung function in obese patients with asthma and control subjects would respond differently to weight loss.Methods: Lung function was evaluated by conventional clinical tests and by impulse oscillometry in female late-onset, nonallergic patients with asthma and control subjects before, and 12 months after, bariatric surgery.Measurements and Main Results: Patients with asthma (n = 10) had significantly lower FEV1 (79.8 ± 10.6 vs. 95.5 ± 7.0%) and FVC (82.4 ± 13.2 vs. 93.7 ± 8.9%) compared with control subjects (n = 13). There were no significant differences in FRC or TLC at baseline. Twelve months after surgery, control subjects had significant increases in FEV1 (95.5 ± 7.0 to 100.7 ± 5.9), FVC (93.6 ± 8.9 to 98.6 ± 8.3%), FRC (45.4 ± 18.5 to 62.1 ± 15.3%), and TLC (84.8 ± 15.0 to 103.1 ± 15.3%), whereas patients with asthma had improvement only in FEV1 (79.8 ± 10.6 to 87.2 ± 11.5). Control subjects and patients with asthma had a significantly different change in respiratory system resistance with weight loss: control subjects exhibited a uniform decrease in respiratory system resistance at all frequencies, whereas patients with asthma exhibited a decrease in frequency dependence of resistance. Fits of a mathematical model of lung mechanics to these impedance spectra suggest that the lung periphery was more collapsed by obesity in patients with asthma compared with control subjects.Conclusions: Weight loss decompresses the lung in both obese control subjects and patients with asthma, but the more pronounced effects of weight loss on lung elastance suggest that the distal lung is inherently more collapsible in people with asthma. äThe Nonallergic Asthma of Obesity A Matter of Distal Lung Compliance (epmc).pdf DeepDyve Pubget Overpricing