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10.1513/AnnalsATS.201308-280OC http://scihub22266oqcxt.onion/10.1513/AnnalsATS.201308-280OC C4225810!4225810!24712298     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Am+Thorac+Soc 2014 ; 11 (5): 728-36 Nephropedia Template TP {{tp|p=24712298|t=2014. Heterogeneous Phenotypes of Acute Respiratory Distress Syndrome after Major Trauma |pdf=|usr=}}{{24712298}} gab.com Text Heterogeneous Phenotypes of Acute Respiratory Distress Syndrome after Major Trauma JO: Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=24712298 #FOAvip Rationale: Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can develop at various times after major trauma.Objectives: To identify and characterize distinct phenotypes of ARDS after trauma, based on timing of syndrome onset.Methods: Latent class analyses were used to identify patterns of ARDS onset in a cohort of critically ill trauma patients. Identified patterns were tested for associations with known ARDS risk factors and associations were externally validated at a separate institution. Eleven plasma biomarkers representing pathophysiologic domains were compared between identified patterns in the validation cohort.Measurements and Main Results: Three patterns of ARDS were identified; class I (52%) early onset on Day 1 or 2, class II (40%) onset on Days 3 and 4, and class III (8%) later onset on Days 4 and 5. Early-onset ARDS was associated with higher Abbreviated Injury Scale scores for the thorax (P < 0.001), lower lowest systolic blood pressure before intensive care unit admission (P = 0.003), and a greater red blood cell transfusion requirement during resuscitation (P = 0.030). In the external validation cohort, early-onset ARDS was also associated with a higher Abbreviated Injury Scale score for the thorax (P = 0.001) and a lower lowest systolic blood pressure before intensive care unit enrollment (P = 0.006). In addition, the early-onset phenotype demonstrated higher plasma levels of soluble receptor for advanced glycation end-products and angiopoietin-2.Conclusions: Degree of hemorrhagic shock and severity of thoracic trauma are associated with an early-onset phenotype of ARDS after major trauma. Lung injury biomarkers suggest a dominant alveolar?capillary barrier injury pattern in this phenotype. Twit Text FOAVip Heterogeneous Phenotypes of Acute Respiratory Distress Syndrome after Major Trauma ????Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=24712298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24712298 #FOAvip English Wikipedia <ref>{{Cite pmid|24712298}}</ref> Heterogeneous Phenotypes of Acute Respiratory Distress Syndrome after Major Trauma #MMPMID24712298 Reilly JP; Bellamy S; Shashaty MGS; Gallop R; Meyer NJ; Lanken PN; Kaplan S; Holena DN; May AK; Ware LB; Christie JD Ann Am Thorac Soc 2014[Jun]; 11 (5): 728-36 PMID24712298show ga Rationale: Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can develop at various times after major trauma.Objectives: To identify and characterize distinct phenotypes of ARDS after trauma, based on timing of syndrome onset.Methods: Latent class analyses were used to identify patterns of ARDS onset in a cohort of critically ill trauma patients. Identified patterns were tested for associations with known ARDS risk factors and associations were externally validated at a separate institution. Eleven plasma biomarkers representing pathophysiologic domains were compared between identified patterns in the validation cohort.Measurements and Main Results: Three patterns of ARDS were identified; class I (52%) early onset on Day 1 or 2, class II (40%) onset on Days 3 and 4, and class III (8%) later onset on Days 4 and 5. Early-onset ARDS was associated with higher Abbreviated Injury Scale scores for the thorax (P < 0.001), lower lowest systolic blood pressure before intensive care unit admission (P = 0.003), and a greater red blood cell transfusion requirement during resuscitation (P = 0.030). In the external validation cohort, early-onset ARDS was also associated with a higher Abbreviated Injury Scale score for the thorax (P = 0.001) and a lower lowest systolic blood pressure before intensive care unit enrollment (P = 0.006). In addition, the early-onset phenotype demonstrated higher plasma levels of soluble receptor for advanced glycation end-products and angiopoietin-2.Conclusions: Degree of hemorrhagic shock and severity of thoracic trauma are associated with an early-onset phenotype of ARDS after major trauma. Lung injury biomarkers suggest a dominant alveolar?capillary barrier injury pattern in this phenotype. äHeterogeneous Phenotypes of Acute Respiratory Distress Syndrome after (epmc).pdf DeepDyve Pubget Overpricing