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10.1038/nrmicro3279 http://scihub22266oqcxt.onion/10.1038/nrmicro3279 C4225775!4225775!24909109     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Microbiol 2014 ; 12 (7): 479-92 Nephropedia Template TP {{tp|p=24909109|t=2014. Unravelling the structural and mechanistic basis of CRISPR?Cas systems |pdf=|usr=}}{{24909109}} gab.com Text Unravelling the structural and mechanistic basis of CRISPR Cas systems JO: Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=24909109 #FOAvip Bacteria and archaea have evolved sophisticated adaptive immune systems, known as CRISPR?Cas (clustered regularly interspaced short palindromic repeats?CRISPR-associated proteins) systems, which target and inactivate invading viruses and plasmids. Immunity is acquired by integrating short fragments of foreign DNA into CRISPR loci, and following transcription and processing of these loci, the CRISPR RNAs (crRNAs) guide the Cas proteins to complementary invading nucleic acid, which results in target interference. In this Review, we summarize the recent structural and biochemical insights that have been gained for the three major types of CRISPR?Cas systems, which together provide a detailed molecular understanding of the unique and conserved mechanisms of RNA-guided adaptive immunity in bacteria and archaea. Twit Text FOAVip Unravelling the structural and mechanistic basis of CRISPR Cas systems ????Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=24909109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24909109 #FOAvip English Wikipedia <ref>{{Cite pmid|24909109}}</ref> Unravelling the structural and mechanistic basis of CRISPR?Cas systems #MMPMID24909109 van der Oost J; Westra ER; Jackson RN; Wiedenheft B Nat Rev Microbiol 2014[Jul]; 12 (7): 479-92 PMID24909109show ga Bacteria and archaea have evolved sophisticated adaptive immune systems, known as CRISPR?Cas (clustered regularly interspaced short palindromic repeats?CRISPR-associated proteins) systems, which target and inactivate invading viruses and plasmids. Immunity is acquired by integrating short fragments of foreign DNA into CRISPR loci, and following transcription and processing of these loci, the CRISPR RNAs (crRNAs) guide the Cas proteins to complementary invading nucleic acid, which results in target interference. In this Review, we summarize the recent structural and biochemical insights that have been gained for the three major types of CRISPR?Cas systems, which together provide a detailed molecular understanding of the unique and conserved mechanisms of RNA-guided adaptive immunity in bacteria and archaea. äUnravelling the structural and mechanistic basis of CRISPR?Cas systems(epmc).pdf DeepDyve Pubget Overpricing